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Chromosomal Instability (CIN) in Cancer

  1. Chris Schmutte

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006069



How to Cite

Schmutte, C. 2006. Chromosomal Instability (CIN) in Cancer. eLS. .

Author Information

  1. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

Publication History

  1. Published Online: 27 JAN 2006


Chromosomal instability is definied as an increased rate of gross chromosomal abnormalities combined with loss of heterozygosity and change in ploidy of genes structural CIN, and the inability of cells to maintain a diploid karyotype numerical CIN.


  • chromosome instability;
  • cancer;
  • selection;
  • Darwinian evolution, microsatelite instability