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Chromatin Structure and Modification: Defects

  1. Brian Hendrich

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006071



How to Cite

Hendrich, B. 2006. Chromatin Structure and Modification: Defects. eLS. .

Author Information

  1. University of Edinburgh, Edinburgh, UK

Publication History

  1. Published Online: 27 JAN 2006


The human genome has evolved a large number of different proteins capable of interacting with or modulating chromatin structure required to ensure the proper regulation of gene expression. Human genetic disease may result from mutation or misexpression of these chromatin proteins.


  • chromatin;
  • deoxyribonucleic acid;
  • human genetic disease;
  • cancer;
  • epigenetics