Mitochondrial Heteroplasmy and Disease
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Elson, J. L. and Lightowlers, R. N. 2006. Mitochondrial Heteroplasmy and Disease. eLS. .
- Published Online: 27 JAN 2006
In addition to the nuclear genome, most eukaryotic cells also have multiple copies of a small circular genome located within the mitochondrion (mtDNA), the presence of which is critical for cellular respiration. All the mtDNA within the cells of young individuals is usually thought to be identical, a condition known as homoplasmy. An alternative situation is heteroplasmy, where there are two or more mtDNA types present within the cells of a single individual.
- mitochondrial deoxyribonucleic acid;
- threshold effect;
- cytoplast transfer;
- random genetic drift