DNA Damage Response
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Khanna, K. K. and Tibbetts, R. S. 2006. DNA Damage Response. eLS. .
- Published Online: 27 JAN 2006
This is not the most recent version of the article. View current version (15 APR 2014)
The deoxyribonucleic acid (DNA) damage response pathway is a surveillance network whereby lesions are eliminated from DNA. DNA damage response detects aberrant DNA and chromosomal structures and coordinates it in some manner with each of the other DNA transactions, including regulation of the cell cycle, DNA repair, replication and under some circumstances the triggering of programmed cell death. Many aspects of DNA damage signaling are highly conserved throughout evolution.
- cell cycle arrest;
- DNA repair;
- ionizing radiation;
- damage detection;
- signal modifiers