Standard Article

DNA Damage Response

  1. Kum Kum Khanna1,
  2. Randal S Tibbetts2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006107

eLS

eLS

How to Cite

Khanna, K. K. and Tibbetts, R. S. 2006. DNA Damage Response. eLS. .

Author Information

  1. 1

    The Queensland Institute of Medical Research, Brisbane, Australia

  2. 2

    The University of Wisconsin, Madison, Wisconsin, USA

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (15 APR 2014)

Abstract

The deoxyribonucleic acid (DNA) damage response pathway is a surveillance network whereby lesions are eliminated from DNA. DNA damage response detects aberrant DNA and chromosomal structures and coordinates it in some manner with each of the other DNA transactions, including regulation of the cell cycle, DNA repair, replication and under some circumstances the triggering of programmed cell death. Many aspects of DNA damage signaling are highly conserved throughout evolution.

Keywords:

  • cell cycle arrest;
  • DNA repair;
  • ionizing radiation;
  • damage detection;
  • signal modifiers