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Heat Shock Proteins (HSPs): Structure, Function and Genetics

  1. Lila Pirkkala1,
  2. Lea Sistonen2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006130

eLS

eLS

How to Cite

Pirkkala, L. and Sistonen, L. 2006. Heat Shock Proteins (HSPs): Structure, Function and Genetics. eLS. .

Author Information

  1. 1

    Hormos Medical Corp., Turku, Finland

  2. 2

    Åbo Akademi University, Turku, Finland

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Heat shock proteins are evolutionarily well-conserved, ATP-binding proteins that function as molecular chaperones in facilitating protein folding and degradation. They are expressed constitutively in various cell types, but the expression of certain family members is strongly induced in response to stress stimuli.

Keywords:

  • heat shock proteins;
  • chaperones;
  • protein folding;
  • protein degradation;
  • heat shock genes