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Exonic Splicing Enhancers

  1. Alexei Fedorov1,
  2. Larisa Fedorova2

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006153



How to Cite

Fedorov, A. and Fedorova, L. 2006. Exonic Splicing Enhancers. eLS. .

Author Information

  1. 1

    Harvard University, Cambridge, Massachusetts, USA

  2. 2

    Tufts University, Boston, Massachusetts, USA

Publication History

  1. Published Online: 27 JAN 2006


Exonic splicing enhancers (ESEs) are short motifs in exons that promote both constitutive and alternative splicing. Several splicing factors, known as SR proteins, bind specifically to ESEs during the initial steps of splicing to initiate assembly of the spliceosomal complex.


  • alternative splicing;
  • exon;
  • intron;
  • sequence motif;
  • enhancer