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Nuclear Receptor Genes

  1. Vincent Laudet

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006154

eLS

eLS

How to Cite

Laudet, V. 2006. Nuclear Receptor Genes. eLS. .

Author Information

  1. Ecole Normale Supérieure de Lyon, Lyon, France

Publication History

  1. Published Online: 27 JAN 2006

Abstract

Nuclear receptors are ligand-dependant transcription factors that can directly regulate target genes in response to hormonal ligands, such as steroids, retinoic acid or thyroid hormones. They form a superfamily of genes that have a complex organization with most often alternative promoters, alternative splicing and autoregulation mechanisms. These genes are dispersed in metazoan genomes and their number varies widely from one genome to another (from 21 in Drosophila to about 270 in nematodes).

Keywords:

  • genomes;
  • gene regulation;
  • human;
  • Drosophila;
  • nematode