Nuclear Receptor Genes
Published Online: 27 JAN 2006
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Laudet, V. 2006. Nuclear Receptor Genes. eLS. .
- Published Online: 27 JAN 2006
Nuclear receptors are ligand-dependant transcription factors that can directly regulate target genes in response to hormonal ligands, such as steroids, retinoic acid or thyroid hormones. They form a superfamily of genes that have a complex organization with most often alternative promoters, alternative splicing and autoregulation mechanisms. These genes are dispersed in metazoan genomes and their number varies widely from one genome to another (from 21 in Drosophila to about 270 in nematodes).
- gene regulation;