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DNA Methylation: Enzymology

  1. Moshe Szyf

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006156



How to Cite

Szyf, M. 2006. DNA Methylation: Enzymology. eLS. .

Author Information

  1. McGill University, Montreal, Canada

Publication History

  1. Published Online: 27 JAN 2006

This is not the most recent version of the article. View current version (14 APR 2015)


In vertebrates, the dinucleotide sequence CG is methylated. The DNA methylation reaction is catalyzed by DNA methyltransferases, which use S-adenosyl-methionine as the methyl donor. In addition to DNA methyltransferases, chromatin modifying and remodeling proteins are involved in creating and replicating DNA methylation patterns. Data suggest that demethylases, enzymes that remove methyl groups from DNA, are involved in shaping DNA methylation patterns.


  • 5-methylcytosine;
  • DNA methylation;
  • chromatin structure;
  • DNA methyltransferases;
  • demethylase;
  • de novo methylation