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Methylated DNA-binding Proteins

  1. Esteban Ballestar,
  2. Manel Esteller

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006157

eLS

eLS

How to Cite

Ballestar, E. and Esteller, M. 2006. Methylated DNA-binding Proteins. eLS. .

Author Information

  1. Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

Publication History

  1. Published Online: 27 JAN 2006

Abstract

The information encoded by deoxyribonucleic acid methylation is interpreted by a family of proteins that share the methylated CpG-binding domain. These proteins are associated with histone deacetylase and mediate gene silencing through the modification of chromatin.

Keywords:

  • DNA methylation;
  • gene repression;
  • histone deacetylase;
  • methylated CpG-binding domain;
  • methyl CpG binding protein 2