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DNA Methylation and Histone Acetylation

  1. Esteban Ballestar,
  2. Manel Esteller

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006158



How to Cite

Ballestar, E. and Esteller, M. 2006. DNA Methylation and Histone Acetylation. eLS. .

Author Information

  1. Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

Publication History

  1. Published Online: 27 JAN 2006


DNA methylation is central to the establishment and heritability of states of expression. Gene silencing that is dependent on DNA methylation involves histone deacetylation. The relevance of the correct maintenance of these modifications patterns is illustrated by cancer, in which alterations in DNA methylation patterns occur.


  • DNA methylation;
  • histone acetylation;
  • epigenetics;
  • hypermethylation;
  • gene repression