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Quantitative Proteomics (ICAT™)

  1. Timothy J Griffin1,
  2. Jamie Sherman2,
  3. Ruedi Aebersold1

Published Online: 27 JAN 2006

DOI: 10.1038/npg.els.0006196



How to Cite

Griffin, T. J., Sherman, J. and Aebersold, R. 2006. Quantitative Proteomics (ICAT™). eLS. .

Author Information

  1. 1

    Institute for Systems Biology, Seattle, Washington, USA

  2. 2

    University of Washington, Seattle, Washington, USA

Publication History

  1. Published Online: 27 JAN 2006


An essential aspect of proteomic analysis is the identification and quantification of each protein present in two or more complex mixtures. The use of isotope-coded affinity tag (ICAT™) reagents and mass spectrometry forms part of quantitative proteomic analysis technology.


  • quantitative proteomics;
  • mass spectrometry;
  • liquid chromatography;
  • two-dimensional gel electrophoresis