Circulating Interleukin-6 in Relation to Adiposity, Insulin Action, and Insulin Secretion
Article first published online: 6 SEP 2012
2001 North American Association for the Study of Obesity (NAASO)
Volume 9, Issue 7, pages 414–417, July 2001
How to Cite
Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A., Bogardus, C. and Pratley, R. E. (2001), Circulating Interleukin-6 in Relation to Adiposity, Insulin Action, and Insulin Secretion. Obesity Research, 9: 414–417. doi: 10.1038/oby.2001.54
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Submitted for publication December 8, 2000. Accepted for publication in final form April 20, 2001
- insulin resistance;
- adipose tissue
Objective: Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes.
Research Methods and Procedures: Fasting plasma IL-6 concentrations (enzyme-linked immunosorbent assay), body composition (DXA), insulin action (M; hyperinsulinemic euglycemic clamp), and acute insulin secretory responses to glucose (25 g intravenous glucose tolerance test) were measured in 58 Pima Indians without diabetes (24 women, 34 men).
Results: Fasting plasma IL-6 concentrations were positively correlated with percentage of body fat (r = 0.26, p = 0.049) and negatively correlated with M (r = −0.28, p = 0.031), but were not related to acute insulin response (r = 0.13, p = 0.339). After adjusting for percentage of body fat, plasma IL-6 was not related to M (partial r = −0.23, p = 0.089).
Discussion: Fasting plasma IL-6 concentrations are positively related to adiposity and negatively related to insulin action in Pima Indians. The relationship between IL-6 and insulin action seems to be mediated through adiposity.