• 1
    Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., Gerich, J. E. (1995) Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333: 550554.
  • 2
    Cusi, K., Consoli, A., DeFronzo, R. A. (1996) Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81: 40594067.
  • 3
    Perriello, G., Misericordia, P., Volgi, E., et al. (1994) Acute antihyperglycemic mechanisms of metformin in NIDDM: evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 43: 920928.
  • 4
    Abbasi, F., Kamath, V., Rizvi, A. A., Carantoni, M., Chen, Y. D., Reaven, G. M. (1997) Results of a placebo-controlled study of the metabolic effects of the addition of metformin to sulfonylurea-treated patients: evidence for a central role of adipose tissue. Diabetes Care 20: 18631869.
  • 5
    Abbasi, F., Carantoni, M., Chen, Y. D., Reaven, G. M. (1998) Further evidence for a central role of adipose tissue in the antihyperglycemic effect of metformin. Diabetes Care 21: 13011305.
  • 6
    Mueller, W. M., Stankope, K. L., Gregoire, F., Evans, J. L., Havel, P. J. (2000) Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obes Res 8: 530539.
  • 7
    Mick, G. J., Wang, X., Fu, Ling C., McCormick, K. L. (2000) Inhibition of leptin secretion by insulin and metformin in cultured rat adipose tissue. Biochim Biophys Acta 1502: 42632.
  • 8
    Paolisso, G., Amato, L., Eccellente, A., et al. (1998) Effect of metformin on food intake in obese subjects. Eur J Clin Invest 28: 441446.
  • 9
    Campbell, I. W., Menzies, D. G., Chalmers, J., et al. (1994) One-year comparative trial of metformin and glipizide in type 2 diabetes mellitus. Diabetes Metab Rev 20: 394400.
  • 10
    Fontbonne, A., Charles, M. A., Juhan-Vague, I., et al. (1996) The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. The BIGPRO Study Group. Diabetes Care 19: 9206.
  • 11
    Lee, A., Morley, J. E. (1998) Metformin decreases food-consumption and induces weight-loss in subjects with obesity with type-II non-insulin-dependent diabetes. Obes Res 6: 4753.
  • 12
    U.K. Prospective Diabetes Study Group (1998) Effect of intensive blood-glucose control with metformin on complications in over-weight patients with type 2 diabetes (UKPDS 34). Lancet 352: 85465.
  • 13
    Matthaei, S., Stumvoll, M., Kellerer, M., Haring, H-U. (2000) Pathophysiology and pharmacological treatment of insulin resistance. Endocrinol Rev 21: 585618.
  • 14
    Makimattila, S., Nikkila, K., Yki-Jarvinen, H. (1999) Causes of weight gain during insulin therapy with and without metformin in patients with type II diabetes. Diabetologia 42: 406412.
  • 15
    Perriello, G., Misericordia, P., Volpi, E., et al. (1994) Acute antihyperglycemic mechanisms of metformin in NIDDM: evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 43: 920928.
  • 16
    Leslie, P., Jung, R. T., Isles, T. E., Baty, J. (1987) Energy expenditure in non-insulin dependent diabetic subjects on metformin or sulfonylurea therapy. Clin Sci 73: 4145.
  • 17
    Pasquali, R., Gambineri, A., Biscotti, D., et al. (2000) Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab 85: 27672774.
  • 18
    Kandarakis, Diamanti E., Kouli, C., Tsianateli, T., Bergiele, A. (1998) Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol 138: 26974.
  • 19
    World Health Organization (1985) Diabetes Mellitus: Report of a WHO Study Group. Technical Report Series 727: World Health Organization Geneva, Switzerland.
  • 20
    Lima, N., Cavaliere, H., Knobel, M., Halperin, A., Medeiros-Neto, G. (2000) Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat. Int J Obes Relat Metab Disord 24: 14331437.
  • 21
    Stanik, S., Dornfeld, L. P., Maxwell, M. H., Viosca, S. P., Korenman, S. G. (1981) The effect of weight loss on reproductive hormones in obese men. J Clin Endocrinol Metab 53: 828832.
  • 22
    Barrett-Connor, E., Khaw, K. T., Yen, S. S. (1990) Endogenous sex hormone levels in older adult men with diabetes mellitus. Am J Epidemiol 132: 895901.
  • 23
    Barrett-Connor, E. (1992) Lower endogenous androgen levels and dyslipidemia in men with non-insulin dependent diabetes mellitus. Ann Intern Med 117: 807811.
  • 24
    Zietz, B., Cuk, A., Hugi, S., et al. (2000) Association of increased C-peptide serum levels and testosterone in type 2 diabetes. Eur J Intern Med 11: 322328.
  • 25
    Birkeland, K. I., Hanssen, K. F., Torjesen, P. A., Vaaler, S. (1993) Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab 76: 275278.
  • 26
    Haffner, S. M., Karhapaa, P., Mykkanen, L., et al. (1994) Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 43: 212219.
  • 27
    Haffner, S. M. (2000) Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation. Int J Obes Relat Metab Disord 24(suppl 2): S56S58.
  • 28
    Evans, D. J., Hoffman, R. G., Kalkhoff, R. K., Kissebah, A. H. (1993) Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 57: 304310.
  • 29
    Plymate, S. R., Matij, L. A., Jones, R. E., Friedl, K. E. (1988) Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep 72) cell line by insulin and prolactin. J Clin Endocrinol Metab 67: 460464.
  • 30
    Strain, G., Zumoff, B., Rosner, W., Pi-Sunyer, X. (1994) The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss. J Clin Endocrinol Metab 79: 11731176.
  • 31
    Isidori, A. M., Caprio, M., Strollo, F., et al. (1999) Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 84: 36733680.
  • 32
    Soderberg, S., Olsson, T., Eliasson, M., et al. (2001) A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adipocity. Int J Obes Relat Metab Disord 25: 98105.
  • 33
    Friedman, J. M., Halaas, J. L. (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763770.
  • 34
    Mantzoros, C. S. (1999) The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 130: 671680.
  • 35
    Cakir, B., Yonem, A., Guler, S., et al. (1999) Relation of leptin and tumor necrosis factor-α to body weight changes in patients with pulmonary tuberculosis. Horm Res 52: 279283.
  • 36
    Halle, M., Berg, A., Garwers, U., Grathwohl, D., Knisel, W., Keul, J. (1999) Concurrent reduction of serum leptin and lipids during weight loss in obese men with type II diabetes. Am J Physiol 277: E277E282.
  • 37
    Haffner, S. M., Hanefeld, M., Fischer, S., Fucker, K., Leonhardt, W. (1997) Glibenclamide, but not acarbose, increases leptin concentrations, parallel to changes in insulin in subjects with NIDDM. Diabetes Care 20: 14301434.
  • 38
    Guler, S., Cakir, B., Demirbas, B., Gursoy, G., Serter, R., Aral, Y. (2000) Leptin concentrations are related to glycaemic control, but do not change with short-term oral antidiabetic therapy in female patients with type 2 diabetes mellitus. Diabetes Obes Metab 2: 313316.
  • 39
    Chu, N. F., Spiegelman, D., Rifai, N., Hotamisligil, G. S., Rimm, E. B. (2000) Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. Int J Obes Relat Metab Disord 24: 10851092.
  • 40
    Moriya, M., Okumura, T., Takahashi, N., Yamagata, K., Motomura, W., Kohgo, Y. (1999) An inverse correlation between serum leptin levels and hemoglobin A1c in patients with non-insulin dependent diabetes mellitus. Diabetes Res Clin Pract 43: 187191.
  • 41
    Ozata, M., Gungor, D., Turan, M., et al. (2001) Improved glycemic control increases fasting plasma acylation stimulating protein (ASP) and decreases leptin concentrations in type 2 diabetic subjects. J Clin Endocrinol Metab 86 (in press).