Effects of the FABP2 A54T Mutation on Triglyceride Metabolism of Viscerally Obese Men
Version of Record online: 6 SEP 2012
2001 North American Association for the Study of Obesity (NAASO)
Volume 9, Issue 11, pages 668–675, November 2001
How to Cite
Berthier, M.-T., Couillard, C., Prud'homme, D., Nadeau, A., Bergeron, J., Tremblay, A., Després, J.-P. and Vohl, M.-C. (2001), Effects of the FABP2 A54T Mutation on Triglyceride Metabolism of Viscerally Obese Men. Obesity Research, 9: 668–675. doi: 10.1038/oby.2001.91
- Issue online: 6 SEP 2012
- Version of Record online: 6 SEP 2012
- Submitted for publication May 1, 2001. Accepted for publication in final form July 09, 2001
- intestinal fatty acid binding protein;
- visceral obesity;
- postprandial lipemia;
Objective: Viscerally obese individuals are frequently characterized by a proatherogenic condition. A missense mutation (A54T) in the fatty acid binding protein type 2 (FABP2) gene has been associated with insulin resistance and obesity. This study examined the effect of this mutation on lipoprotein levels in viscerally obese hyperinsulinemic condition.
Research Methods and Procedures: A total of 217 men were assigned to one of two groups based on their FABP2 A54T polymorphism.
Results: The two genotypic groups showed no difference in either physiological characteristics or lipoprotein/lipid profile, before or after statistical adjustment for age. From this initial sample, 50 men accepted to have their postprandial lipid response assessed and 10 T54/A54 heterozygotes were then individually matched for visceral adipose tissue accumulation and fasting plasma triglyceride (TG) levels with 10 A54/A54 homozygotes. High-density lipoprotein (HDL)-TG levels were significantly increased in the fasting state as well as 4 hours after the test meal (p = 0.04 and p = 0.0008, respectively) in men bearing the A54T mutation. In addition, the area under the curve of postprandial HDL-TG levels was also significantly higher among T54/A54 heterozygotes than among A54/A54 homozygotes (p = 0.04). Interestingly, fasting TG concentrations in large TG-rich lipoproteins (large-TRL; Sf > 400) were correlated with HDL-TG levels at 4 (r = 0.74, p = 0.01) and 8 hours (r = 0.73, p = 0.01) after the test meal in T54/A54 heterozygotes only.
Discussion: The FABP2 A54T missense mutation may contribute to the TG enrichment of HDL in the postprandial state that, in turn, may alter the risk of atherosclerotic vascular disease.