• 1
    Barsh, G. S., Farooqi, Sadat I., O'Rahilly, S. (2000) Genetics of body weight regulation. Nature; 404:64451.
  • 2
    Pérusse, L., Chagnon, Y. C., Weisnagel, S. J. et al. (2001) The human obesity gene map: the 2000 update. Obes Res. 9:13569.
  • 3
    Larsson, B., Svardsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P., Tibblin, G.. (1984) Abdominal adipose tissue distribution obesity and risk of cardiovascular disease and death: 13-year follow-up of participants in the study of men born in 1913. Br Med J. 288: 14011404.
  • 4
    Buemann, B., Vohl, M. C., Chagnon, M., et al. (1997) Abdominal visceral fat is associated with a BcII restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res 5: 186192.
  • 5
    Ukkola, O., Rankinen, T., Weisnagel, S. J., et al. (2000) Interactions among the α2-, β2-, and β3-adrenergic receptor genes and obesity-related phenotypes in the Quebec Family Study. Metabolism 49: 10631070.
  • 6
    Hager, J., Hansen, L., Vaisse, C., et al. (1995) A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat Genet 9: 299304.
  • 7
    Chambers, S. M., Morris, B. J. (1996) Glucagon receptor gene mutation in essential hypertension. Nat Genet 12: 122.
  • 8
    Brand, E., Bankir, L., Plouin, P. F., Soubrier, F. (1999) Glucagon receptor gene mutation (Gly40Ser) in human essential hypertension: the PEGASE study. Hypertension 34: 1517.
  • 9
    Tonolo, G., Melis, M. G., Ciccarese, M., et al. (1997) Physiological and genetic characterization of the Gly40Ser mutation in the glucagon receptor gene in the Sardinian population. The Sardinian Diabetes Genetic Study Group. Diabetologia 40: 8994.
  • 10
    Ristow, M., Busch, K., Schatz, H., Pfeiffer, A. (1996) Restricted geographical extension of the association of a glucagon receptor gene mutation (Gly40Ser) with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 32: 1835.
  • 11
    Gerich, J. E. (1981) Physiology of glucagon. Int Rev Physiol 24: 243275.
  • 12
    Geary, N., Le Sauter, J., Noh, U. (1993) Glucagon acts in the liver to control spontaneous meal size in rats. Am J Physiol 264: R11622.
  • 13
    Cappuccio, F. P., Strazzullo, P., Farinaro, E., Trevisan, M. (1993) Uric acid metabolism and tubular sodium handling: results from a population-based study. J Am Med Assoc 270: 354359.
  • 14
    Strazzullo, P., Iacone, R., Siani, A., et al. (2001) Relationship of the Trp64Arg polymorphism of the β3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age: cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. J Hypertens 19: 399406.
  • 15
    National Institutes of Health, National Heart, Lung, and Blood Institute (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res 6(suppl 2): 51S209.
  • 16
    Kahn, H. S., Simoes, E. J., Koponen, M., Hanzlick, R. (1996) The abdominal diameter index and sudden coronary death in men. Am J Cardiol 78: 961964.
  • 17
    Lahiri, D. K., Numberger, J. J. (1981) A rapid non-enzymatic method for preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Res 19: 54445447.
  • 18
    Meigs, J. B., D'Agostino, R. B., Sr Wilson, P. W., Cupples, L. A., Nathan, D. M., Singer, D. E. (1997) Risk variable clustering in the insulin resistance syndrome. The Framingham Off spring Study. Diabetes 46: 15941600.
  • 19
    Kopelman, P. G. (2000) Obesity as a medical problem. Nature 404: 635643.
  • 20
    Christophe, J. (1995) Glucagon receptors: from genetic structure and expression to effector coupling and biological responses. Biochim Biophys Acta 1241: 4557.
  • 21
    Hansen, L. H., Abrahamsen, N., Hager, J., et al. (1996) The Gly40Ser mutation in the human glucagon receptor gene associated with NIDDM results in a receptor with reduced sensitivity to glucagon. Diabetes 45: 725730.
  • 22
    Perea, A., Clemente, F., Martinell, J., Villanueva-Penacarrillo, M. L., Valverde, I. (1995) Physiological effect of glucagon in human isolated adipocytes. Horm Metab Res 27: 372375.
  • 23
    Carlson, M. G., Snead, W. L., Campbell, P. J. (1993) Regulation of free fatty acid metabolism by glucagon. J Clin Endocrinol Metab 77: 115.
  • 24
    Bergman, R. N., van Citters, G. W., Mittelman, S. D., et al. (2001) Central role of the adipocyte in the metabolic syndrome. J Invest Med 49: 119126.
  • 25
    Strazzullo, P., Iacone, R., Siani, A., et al. (2001) Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. J Mol Med (in press).