• 1
    Flegal, K. M., Carroll, M. D., Kuczmarski, R. J., Johnson, C. L. (1998) Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord 22: 3947.
  • 2
    Manson, J. E., Colditz, G. A., Stampfer, M. J., et al. (1990) A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 322: 882889.
  • 3
    Folsom, A. R., Kaye, S. A., Sellers, T. A., et al. (1993) Body fat distribution and 5-year risk of death in older women. JAMA 269: 483487.
  • 4
    Goodpaster, B. H., Thaete, F. L., Simoneau, J-A, Kelley, D. E. (1997) Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46: 15791585.
  • 5
    Simoneau, J-A, Colberg, S. R., Thaete, F. L., Kelley, D. E. (1995) Skeletal muscle glycolytic and oxidative enzyme capacities and determinants of insulin sensitivity and muscle composition in obese women. FASEB J 9: 273278.
  • 6
    Ryan, A. S., Nicklas, B. J. (1999) Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors. Int J Obes Relat Metab Disord 23: 126132.
  • 7
    Lundgren, H., Bengtsson, C., Blohme, G., Lapidus, L., Sjöström, L. (1989) Adiposity and adipose tissue distribution in relation to incidence of diabetes in women: results from a prospective population study in Gothenburg, Sweden. Int J Obes Relat Metab Disord 13: 413423.
  • 8
    Kuczmarski, R. J., Flegal, K. M., Campbell, S. M., Johnson, C. L. (1994) Increasing prevalence of overweight among US adults. JAMA 272: 205211.
  • 9
    Lipton, R. B., Liao, Y., Cao, G., Cooper, R. S., McGee, D. (1993) Determinants of incident non-insulin-dependent diabetes mellitus among blacks and whites in a national sample. Am J Epidemiol 138: 826839.
  • 10
    Brancati, F. L., Kao, W. H. L., Folsom, A. R., Watson, R. L., Szklo, M. (2000) Incident type 2 diabetes mellitus in African American and white adults. JAMA 283: 22532259.
  • 11
    Kushner, R. F., Racette, S. B., Neil, K., Schoeller, D. A. (1995) Measurement of physical activity among blacks and white obese women. Obes Res 3: 261S265S.
  • 12
    Carpenter, W. H., Fonong, T., Toth, M. J., et al. (1998) Total daily energy expenditure in free-living older African-Americans and Caucasians. Am J Physiol Endocrinol Metab 274: E96E101.
  • 13
    Nicklas, B. J., Berman, D. M., Davis, D. C., Dobrovolny, C. L., Dennis, K. E. (1999) Racial differences in metabolic predictors of obesity among postmenopausal women. Obes Res 7: 463468.
  • 14
    Conway, J. M., Yanoski, S. Z., Avila, N. A., Hubbard, V. S. (1995) Visceral adipose tissue differences in black and white women. Am J Clin Nutr 61: 765771.
  • 15
    Albu, J. B., Murphy, L., Frager, D. H., Johnson, J. A., Pi-Sunyer, F. X. (1997) Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Diabetes 46: 456462.
  • 16
    Lovejoy, J. C., de la Bretonne, J., Klemperer, M., Tulley, R. (1996) Abdominal fat distribution and metabolic risk factors: effects of race. Metabolism 45: 11191124.
  • 17
    Marcus, M. A., Murphy, L., Pi-Sunyer, F. X., Albu, J. B. (1999) Insulin sensitivity and serum triglyceride level in obese white and black women: relationship to visceral and truncal subcutaneous fat. Metabolism 48: 194199.
  • 18
    Poehlman, E. T., Toth, M. J., Gardner, A. W. (1995) Changes in energy balance and body composition at menopause: a controlled longitudinal study. Arch Intern Med 123: 673675.
  • 19
    Campbell, P. J., Gerich, J. E. (1990) Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metab 70: 11141118.
  • 20
    Kolterman, O. G., Insel, J., Saekow, M., Olefsky, J. M. (1980) Mechanisms of insulin resistance in human obesity. Evidence for receptor and postreceptor defects. J Clin Invest 65: 12721284.
  • 21
    Report of the expert committee on the diagnosis and classification of diabetes mellitus. (1997) Diabetes Care 20: 11831197.
  • 22
    Ryan, A. S., Pratley, R. E., Elahi, D., Goldberg, A. P. (1995) Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women. J Appl Physiol 79: 818823.
  • 23
    Lohman, T. G. Roche, A. F. Martell, R. eds. (1988) The Anthropometric Standardization Reference Manual. Human Kinetics Publishing Champaign, IL.
  • 24
    Meneilly, G. S., Elliot, T. (1999) Metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes. Diabetes Care 22: 112118.
  • 25
    Harris, J. A., Benedict, F. G. (1919) A Biometric Study of Basal Metabolism in Man 279 Carnegie Institute Washington, DC.
  • 26
    Rodwell, W.S (1985) Nutrition and Diet Therapy 112113. Times Mirror/Mosby St. Louis, MO.
  • 27
    DeFronzo, R. A., Tobin, J. D., Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab 237: E214E233.
  • 28
    McGuire, E. A. H., Helderman, J. H., Tobin, J. D., Andres, R. (1976) Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41: 565573.
  • 29
    Lusk, G. (1924) The Elements of the Science of Nutrition Saunders New York.
  • 30
    Wolfe, R. (1992) Radioactive and Stable Isotope Tracers in Biomedicine Wiley-Liss New York.
  • 31
    Ryan, A. S., Pratley, R. E., Goldberg, A. P., Elahi, D. (1996) Increased insulin sensitivity in post-menopausal women following resistive training and weight loss. J Gerontol 51A: M199M205.
  • 32
    Elahi, D., Nagulesparan, M., Hershcopf, R. J., et al. (1982) Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med 306: 11961202.
  • 33
    Tull, E. S., Roseman, J. M. (1995) Diabetes in African Americans. National Diabetes Data Group, eds.. Diabetes in America U.S. Dept. of Health and Human Services Bethesda, MD.613630.
  • 34
    Harris, M. I., Hadden, W. C., Knowler, W. C., Bennett, P. H. (1987) Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20–74 yr. Diabetes 36: 523534.
  • 35
    O'Brien, T. R., Flanders, D., Decoufle, P., Boyle, C. A., DeStefano, F., Teutsch, S. (1989) Are racial differences in the prevalence of diabetes in adults explained by differences in obesity? JAMA 262: 14851488.
  • 36
    Haffner, S. M., D'Agostino, R., Saad, M. F., et al. (1996) Increased insulin resistance and insulin secretion in nondiabetic African Americans and Hispanics compared with non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. Diabetes 45: 742748.
  • 37
    Abate, N., Garg, A., Peshock, R. M., Stray-Gundersen, J., Grundy, S. M. (1995) Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96: 8898.
  • 38
    Rice, C. L., Cunningham, D. A., Paterson, D. H., Lefcoe, M. S. (1989) Arm and leg composition determined by computed tomography in young and elderly men. Clin Physiol 9: 207220.
  • 39
    Kelley, D. E., Slasky, B. S., Janosky, J. (1991) Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus. Am J Clin Nutr 54: 509515.
  • 40
    Goodpaster, B. H., Kelley, D. E., Thaete, F. L., He, J., Ross, R. (2000) Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol 89: 104110.
  • 41
    Bondonna, R. C., Bonora, E. (1997) Glucose and free fatty acid metabolism in human obesity. Diabetes Rev 5: 2151.
  • 42
    Virkamaki, A., Ueki, K., Kahn, C. R. (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103: 931943.
  • 43
    Phillips, D. I. W., Caddy, S., Ilic, V., et al. (1996) Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947950.
  • 44
    Storlien, L., Jenkins, A., Chisholm, D., Pascoe, W., Khouri, S., Kraegen, E. (1991) Influence of dietary fat composition on development of insulin resistance in rats: relationship to muscle triglyceride and w3 fatty acids in muscle phospholipid. Diabetes 40: 280289.
  • 45
    Zillikens, M. C., Conway, J. M. (1990) Anthropometry in blacks: applicability of generalized skinfold equations and differences in fat patterning between blacks and whites. Am J Clin Nutr 52: 4551.
  • 46
    Hill, J. O., Sidney, S., Lewis, C. E., Tolan, K., Scherzinger, A. l., Stamm, E. R. (1999) Racial differences in amounts of visceral adipose tissue in young adults: the CARDIA (Coronary Artery Risk Development in Young Adults) Study. Am J Clin Nutr 69: 381387.
  • 47
    Lovejoy, J. C., Smith, S. R., Rood, J. C. (2001) Comparison of regional fat distribution and health risk factors in middle-aged white and African American women: the Healthy Transitions Study. Obes Res 9: 1016.
  • 48
    Aloia, J. F., Vaswani, A., Mikhail, M., Flaster, E. R. (1999) Body composition by dual-energy X-ray absorptiometry in black compared to white women. Osteoporos Int 10: 114119.
  • 49
    Weinsier, R. L., Hunter, G. R., Zuckerman, P. A., et al. (2000) Energy expenditure and free-living physical activity in black and white women: comparison before and after weight loss. Am J Clin Nutr 71: 11381146.
  • 50
    Ryan, A. S., Nicklas, B. J., Berman, D. M., Dennis, K. E. (2000) Dietary restriction and walking reduce fat deposition in the mid-thigh in obese older women. Am J Clin Nutr 72: 708713.