Hypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity
Article first published online: 6 SEP 2012
2003 North American Association for the Study of Obesity (NAASO)
Volume 11, Issue 9, pages 1147–1154, September 2003
How to Cite
Kok, S. W., Overeem, S., Visscher, T. L.S., Lammers, G. J., Seidell, J. C., Pijl, H. and Meinders, A. E. (2003), Hypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity. Obesity Research, 11: 1147–1154. doi: 10.1038/oby.2003.156
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review January 13, 2003; Accepted in final form July 24, 2003
- waist circumference;
- body fat;
- body weight
Objective: To determine the prevalence of obesity among patients with narcolepsy, to estimate associated long-term health risks on the basis of waist circumference, and to distinguish the impact of hypocretin deficiency from that of increased daytime sleepiness (i.e., reduced physical activity) on these anthropometric measures.
Research Methods and Procedures: A cross-sectional, case-control study was conducted. Patients with narcolepsy (n = 138) or idiopathic hypersomnia (IH) (n = 33) were included. Age-matched, healthy members of the Dutch population (Monitoring Project on Risk Factors for Chronic Diseases and Doetinchem Project; n = 10, 526) were used as controls. BMI and waist circumference were determined.
Results: Obesity (BMI ≥ 30 kg/m2) and overweight (BMI 25 to 30 kg/m2) occurred more often among narcolepsy patients [prevalence: 33% (narcoleptics) vs. 12.5% (controls) and 43% (narcoleptics) vs. 36% (controls), respectively; both p < 0.05]. Narcoleptics had a larger waist circumference (mean difference 5 ± 1.4 cm, p < 0.001). The BMI of patients with IH was significantly lower than that of narcolepsy patients (25.6 ± 3.6 vs. 28.5 ± 5.4 kg/m2; p = 0.004).
Discussion: Overweight and obesity occur frequently in patients with narcolepsy. Moreover, these patients have an increased waist circumference, indicating excess fat storage in abdominal depots. The fact that patients with IH had a lower BMI than narcoleptics supports the notion that excessive daytime sleepiness (i.e., inactivity) cannot account for excess body fat in narcoleptic patients.