SEARCH

SEARCH BY CITATION

References

  • 1
    Engeli, S., Bohnke, J., Feldpausch, M., et al (2004) Regulation of 11β-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res 12: 917.
  • 2
    Seckl, J. R., Walker, BR. (2001) 11beta-hydroxysteroid dehydrogenase type 1–a tissue-specific amplifier of glucocorticoid action. Endocrinology 142: 13711376.
  • 3
    Walker, B. R., Connacher, A. A., Lindsay, R. M., Webb, D. J., Edwards, CRW. (1995) Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab. 80: 31553159.
  • 4
    Bujalska, I. J., Kumar, S., Stewart, PM. (1997) Does central obesity reflect ‘Cushing's disease of the omentum’? Lancet. 349: 12101213.
  • 5
    Kotelevtsev, Y. V., Holmes, M. C., Burchell, A., et al (1997) 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity or stress. Proc Natl Acad Sci U S A. 94: 1492414929.
  • 6
    Morton, N. M., Holmes, M. C., Fievet, C., et al (2001) Improved lipid, lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem. 276: 4129341300.
  • 7
    Masuzaki, H., Paterson, J., Shinyama, H., et al (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science. 294: 21662170.
  • 8
    Masuzaki, H., Yamamoto, H., Kenyon, C. J., et al (2003) Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest. 112: 8390.
  • 9
    Andrew, R., Phillips, D. I. W., Walker, BR. (1998) Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab. 83: 18061809.
  • 10
    Fraser, R., Ingram, M. C., Anderson, N. H., Morrison, C., Davies, E., Connell, JMC. (1999) Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension. 33: 13641368.
  • 11
    Stewart, P. M., Boulton, A., Kumar, S., Clark, P. M. S., Shackleton, CHL. (1999) Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab. 84: 10221027.
  • 12
    Rask, E., Olsson, T., Soderberg, S., et al (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab. 86: 14181421.
  • 13
    Reynolds, R. M., Walker, B. R., Phillips, D. I. W., et al (2001) Altered control of cortisol secretion in adult men with low birth weight and cardiovascular risk factors. J Clin Endocrinol Metab. 86: 245250.
  • 14
    Rask, E., Walker, B. R., Soderberg, S., et al (2002) Tissue-specific changes in peripheral cortisol metabolism in obese women; increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab. 87: 33303336.
  • 15
    Tiosano, D., Eisentein, I., Militianu, D., Chrousos, G. P., Hochberg, Z. (2003) 11beta-hydroxysteroid dehydrogenase activity in hypothalamic obesity. J Clin Endocrinol Metab. 88: 379384.
  • 16
    Westerbacka, J., Yki-Jarvinen, H., Vehkavaara, S., et al (2003) Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab. 88: 49244931.
  • 17
    Lindsay, R. S., Tataranni, A., Permana, P., Livingstone, D. E. W., Wake, D. J., Walker, BR. (2003) Subcutaneous adipose 11beta-hydroxysteroid dehydrogenase type 1 activity and mRNA levels are associated with adiposity and insulinaemia in Pima Indians and Caucasians. J Clin Endocrinol Metab. 88: 27382744.
  • 18
    Wake, D. J., Rask, E., Livingstone, D. E. W., Soderberg, S., Olsson, T., Walker, BR. (2003) Local and systemic impact of transcriptional upregulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab. 88: 29832988.
  • 19
    Paulmyer-Lacroix, O., Boullu, S., Oliver, C., Alessi, M-C, Grino, M. (2002) Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab. 87: 27012705.
  • 20
    Tomlinson, J. W., Sinha, B., Bujalska, I., Hewison, M., Stewart, PM. (2002) Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab. 87: 56305635.
  • 21
    Tomlinson, J. W., Moore, J., Cooper, M. S., et al (2001) Regulation of expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology. 142: 19821989.
  • 22
    Livingstone, D. E. W., Kenyon, C. J., Walker, BR. (2000) Mechanisms of dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 in Zucker obese rats. J Endocrinol. 167: 533539.
  • 23
    Liu, Y., Nakagawa, Y., Wang, Y., et al (2003) Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 52: 14091416.
  • 24
    Draper, N., Echwald, S. M., Lavery, G. G., et al (2002) Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. J Clin Endocrinol Metab. 87: 49844990.
  • 25
    Caramelli, E., Strippoli, P., Di Giacomi, T., Tietz, C., Carinci, P., Pasquali, R. (2001) Lack of mutations of type 1 11[beta]-hydroxysteroid dehydrogenase gene in patients with abdominal obesity. Endocr Res. 27: 4761.
  • 26
    Andrews, R. C., Rooyackers, O., Walker, BR. (2003) Effects of the 11beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes. J Clin Endocrinol Metab. 88: 285291.
  • 27
    Livingstone, D. E. W., Walker, BR. (2003) Is 11beta-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats. J Pharmacol Exp Ther. 305: 167172.
  • 28
    Alberts, P., Engblom, L., Edling, N., et al (2002) Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 45: 15281532.
  • 29
    Alberts, P., Nilsson, C., Selen, G., et al (2003) Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycaemic mice strains. Endocrinology. 144: 47554762.
  • 30
    Bujalska, I. J., Walker, E. A., Hewison, M., Stewart, PM. (2002) A switch in dehydrogenase to reductase activity of 11beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells. J Clin Endocrinol Metab. 87: 12051210.
  • 31
    Ozols, J. (1995) Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase. J Biol Chem. 270: 23052312.
  • 32
    Draper, N., Walker, E. A., Bujalska, I. J., et al (2003) Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet. 34: 434439.
  • 33
    Christy, C., Hadoke, P. W. F., Paterson, J. M., Mullins, J. J., Seckl, J. R., Walker, BR. (2003) Glucocorticoid action in mouse aorta; localisation of 11beta-hydroxysteroid dehydrogenase type 2 and effects on responses to glucocorticoids in vitro. Hypertension. 42: 580587.