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Adiponectin But Not Resistin Is Associated with Insulin Resistance-Related Phenotypes in Baboons
Article first published online: 6 SEP 2012
2004 North American Association for the Study of Obesity (NAASO)
Volume 12, Issue 5, pages 871–877, May 2004
How to Cite
Tejero, M. E., Freeland-Graves, J. H., Proffitt, J. M., Peebles, K. W., Cai, G., Cole, S. A. and Comuzzie, A. G. (2004), Adiponectin But Not Resistin Is Associated with Insulin Resistance-Related Phenotypes in Baboons. Obesity Research, 12: 871–877. doi: 10.1038/oby.2004.105
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review May 20, 2003; Accepted in final form March 18, 2004
Objectives: The hormones adiponectin and resistin have been associated with insulin resistance. This paper analyzed the potential relationship between adiponectin and resistin and insulin resistance-related phenotypes in baboons.
Research Methods and Procedures: One hundred eight adult baboons (84 female and 24 male) were studied. Weight was measured, and a blood sample was collected under fasting conditions for plasma and monocyte isolation. Fasting glucose, insulin, C-peptide, and adiponectin levels in plasma were measured by standard methods. Insulin resistance was calculated by the homeostasis model assessment index. Resistin mRNA abundance in monocytes was determined by real-time quantitative reverse transcription-polymerase chain reaction. Data were clustered by weight tertiles for statistical analysis.
Results: As observed in humans, the insulin resistance-related phenotypes were related to weight, plasma levels of adiponectin, and C-peptide. No significant relationship between resistin circulating levels or expression in monocytes and insulin resistance-related phenotypes was found in baboons.
Discussion: These findings suggest that resistin is not associated with insulin resistance. However, previous observations of relationships among weight, adiponectin, and insulin resistance are confirmed.