• 1
    James, P. T., Leach, R., Kalamara, E., Shayeghi, M. (2001) The worldwide obesity epidemic. Obes Res. 9(Suppl 4): S228S233.
  • 2
    Mokdad, A. H., Bowman, B. A., Ford, E. S., Vinicor, F., Marks, J. S., Koplan, J. P. (2001) The continuing epidemics of obesity and diabetes in the United States. JAMA 286: 11951200.
  • 3
    Flegal, K. M., Carroll, M. D., Ogden, C. L., Johnson, C. L. (2002) Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288: 17231727.
  • 4
    Bergström, A., Pisani, P., Tenet, V., Wolk, A., Adami, H-O (2001) Overweight as an avoidable cause of cancer in Europe. Int J Cancer 91: 421430.
  • 5
    WHO Press Release WHO/46;12 June 1997. Obesity epidemic puts millions at risk from related diseases [press release]. Available at: http:www.who.intarchivesinf-pr-1997enpr97-46.html. Accessed August 13, 2003.
  • 6
    Tee, E. S. (2002) Obesity in Asia: prevalence and issues in assessment methodologies. Asia Pac J Clin Nutr. 11(Suppl 8): S694S701.
  • 7
    Resnick, H. E., Valsania, P., Halter, J. B., Lin, X. (2000) Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults. J Epidemiol Community Health 54: 596602.
  • 8
    Wilson, P. W. F., D'Agostino, R. B., Sullivan, L., Parise, H., Kannel, W. B. (2002) Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 162: 18671872.
  • 9
    Brown, C. D., Higgins, M., Donato, K. A., et al. (2000) Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res. 8: 605619.
  • 10
    Kaufman, J. S., Durazo-Arvizu, R. A., Rotimi, C. N., McGee, D. L., Cooper, R. S. (1996) Obesity and hypertension prevalence in populations of African origin: the Investigators of the International Collaborative Study on Hypertension in Blacks. Epidemiology 7: 398405.
  • 11
    Rimm, E. B., Stampfer, M. J., Giovannucci, E., et al. (1995) Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol. 141: 11171127.
  • 12
    Rexrode, K. M., Hennekens, C. H., Willett, W. C., et al. (1997) A prospective study of body mass index, weight change, and risk of stroke in women. JAMA 277: 15391545.
  • 13
    Hochberg, M. C., Lethbridge-Cejku, M., et al. (1995) The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 22: 488493.
  • 14
    Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., Heath, C. W. (1999) Body-mass index and mortality in a prospective cohort of U.S. adults. New Engl J Med. 341: 10971105.
  • 15
    NIH Technology Assessment Conference Panel. (1993) Methods for voluntary weight loss and control: Consensus Development Conference, 30 March to 1 April 1992. Ann Intern Med. 119: 764770.
  • 16
    Knowler, W. C., Barrett-Connor, E., Diabetes Prevention Program (DPP) Research Group. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 346: 393403.
  • 17
    Sjöström, L., Rissanen, A., Andersen, T., et al. (1998) Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese subjects: European Multicentre Orlistat Study Group. Lancet. 352: 167172.
  • 18
    Davidson, M. H., Hauptmann, J., DiGirolamo, M., et al. (1999) Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA 281: 235242.
  • 19
    Rössner, S., Sjöström, L., Noack, R., Meinders, A. E., Noseda, G. (2000) Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity: European Orlistat Obesity Study Group. Obes Res. 8: 4961.
  • 20
    James, W. P. T., Astrup, A., Finer, N., et al. (2000) Effect of sibutramine on weight maintenance after weight loss: a randomised trial. Lancet. 356: 21192125.
  • 21
    Apfelbaum, M., Vague, P., Ziegler, O., Hanotin, C., Thomas, F., Leutenegger, E. (1999) Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine. Am J Med. 106: 179184.
  • 22
    Richard, D., Ferland, J., Lalonde, J., Samson, P., Deshaies, Y. (2000) Influence of topiramate in the regulation of energy balance. Nutrition 16: 961966.
  • 23
    Bray, G. A., Hollander, P., Klein, S., et al. (2003) A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res. 11: 722733.
  • 24
    Energy and protein requirements: report of a joint FAO/WHO/UNU expert consultation. (1985) WHO Geneva, Technical report series no. 72471.
  • 25
    Dunnett, C. W., Tamhane, A. C. (1991) Step-down multiple tests for comparing treatments with a control in unbalanced one-way layout. Stat Med. 10: 939947.
  • 26
    Dodgson, S. J., Shank, R. P., Maryanoff, B. E. (2000) Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia 41(Suppl 1): S35S39.
  • 27
    Hill, J. O., Wyatt, H. R., Reed, G. W., Peters, J. C. (2003) Obesity and the environment: where do we go from here? Science 299: 853855.
  • 28
    Richard, D., Picard, F., Lemieux, C., Lalonde, J., Samson, P., Deshaies, Y. (2002) The effects of topiramate and sex hormones on energy balance of male and female rats. Int J Obes Relat Metab Disord. 26: 344353.
  • 29
    York, D. A., Singer, L., Thomas, S., Bray, G. A. (2000) Effect of topiramate on body weight and body composition of Osborne-Mendel rats fed a high-fat diet: alterations in hormones, neuropeptide, and uncoupling-protein mRNAs. Nutrition 16: 967975.
  • 30
    White, H. S., Brown, S. D., Woodhead, J. H., Skeen, G. A., Wolf, H. H. (1997) Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res. 28: 167179.
  • 31
    Gibbs, J. W., 3rd, Sombati S, DeLorenzo RJ, Coulter DA (2000) Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons. Epilepsia 41(Suppl 1): S10S16.
  • 32
    Taverna, S., Sancini, G., Mantegazza, M., Franceschetti, S., Avanzini, G. (1999) Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate. J Pharmacol Exp Ther. 288: 960968.