• 1
    Terenius, L. (1967) Inhibition of 17-beta-oestradiol uptake in mouse uterus by doisynolic and allenoic acid derivatives: an in vitro differentiation between true oestrogens and pro-oestrogens. Acta PharmacolToxicol. 25: 313322.
  • 2
    Meyers, C. Y., Hou, Y., Winters, T. A., Banz, W. J., Adler, S. (2002) Activities of a non-classical estrogen, Z-bis-dehydrodoisynolicacid, with ERalpha and ERbeta. J Steroid Biochem Mol Biol. 82: 3344.
  • 3
    Meyers, C. Y., Hou, Y., Robinson, P. D., Adler, S., Banz, W. J., Winters, TA. (2000) Absolute structure determination of the highly biologically active bisdehydrodoisynolic acids. J Pharm Sci. 89: 513518.
  • 4
    Meyers, C. Y., Lutfi, H. G., Adler, S. (1997) Transcriptional regulation of estrogen-responsive genes by non-steroidal estrogens: doisynolic and allenolic acids. J Steroid Biochem Mol Biol. 62: 477489.
  • 5
    Meyers, C. Y., Kolb, V. M., Gass, G. H., Rao, B. R., Roos, C. F., Dandliker, WB. (1988) Doisynolic-type acids: uterotropically potent estrogens which compete poorly with estradiol for cytosolic estradiol receptors. J Steroid Biochem. 31: 393404.
  • 6
    Meyers, CY. (1995) Doisynolic acid type compounds as weight and appetite suppressing and control agents. Patent 5420161.
  • 7
    Wilson, T., March, H., Banz, W. J., et al (2002) Antioxidant effects of phyto-and synthetic-estrogens on cupric ion-induced oxidation of human low-density lipoproteins in vitro. Life Sci. 70: 22872297.
  • 8
    Banz, W. J., Winters, T. A., Hou, Y., Adler, S., Meyers, CY. (1998) Comparative effects of the selective estrogen receptor modulators (−)-, (+)- and (+/−)-Z bisdehydrodoisynolic acids on metabolic and reproductive parameters in male and female rats. Horm Metab Res. 30: 730736.
  • 9
    Djouadi, F., Weinheimer, C. J., Saffitz, J. E., et al (1998) A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha- deficient mice. J Clin Invest. 102: 10831091.
  • 10
    Mezei, O., Banz, W. J., Steger, R. W., Peluso, M. R., Winters, T. A., Shay, N. (2003) Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J Nutr. 133: 12381243.
  • 11
    Mayer, DF. (2002) Raloxifene and risk of cardiovascular events. JAMA 288: 4243.
  • 12
    Oleksik, A. M., Duong, T., Pliester, N., Asma, G., Popp-Snijders, C., Lips, P. (2001) Effects of the selective estrogen receptor modulator, raloxifene, on the somatotropic axis and insulin-glucose homeostasis. J Clin Endocrinol Metab. 86: 27632768.
  • 13
    Finkelstein, JA. (1986) Long-term effects of diethylstilbestrol (DES) on genetically obese and non-obese female Zucker rats. Brain Res Bull 17: 885888.
  • 14
    Gale, S. K., Van Itallie, TB. (1979) Genetic obestiy: estrogenic influences on the body weight and food intake of lean and obese adult Zucker (fa/fa) rats. Physiol Behav. 23: 111120.
  • 15
    Gray, J. M., Greenwood, MR. (1984) Effect of estrogen on lipoprotein lipase activity and cytoplasmic progestin binding sites in lean and obese Zucker rats. Proc Soc Exp Biol Med. 175: 374379.
  • 16
    Stevenson, F. T., Wheeldon, C. M., Gades, M. D., Kaysen, G. A., Stern, J. S., van Goor, H. (2000) Estrogen worsens incipient hypertriglyceridemic glomerular injury in the obese Zucker rat. Kidney Int. 57: 19271935.
  • 17
    Wilson, J. N., Wilson, S. P., Eaton, RP. (1982) Influence of genetic hyperlipemia in the Zucker rat upon the lipemic response to graded estradiol exposure. Atherosclerosis 41: 99114.
  • 18
    Unger, R. H., Orci, L. (2002) Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 1585: 202212.
  • 19
    Cheng, A. Y., Fantus, IG. (2004) Thiazolidinedione-induced congestive heart failure. Ann Pharmacother. 38: 817820.
  • 20
    Meyers, C. Y., Banz, W. J., Adler, S. R., Winters, T. A., Hou, Y., Dandliker, WB. (2003) Method for treating or preventing prostatic conditions. Patent 6, 608, 111.
  • 21
    Henry, N., Hou, Y., Roeder, M., et al (2001) Effects of (+)-Z-bisdehydrodoisynolic acid on the rat prostate. Biol Reprod. 64: 227 (abstr).
  • 22
    Reeves, P. G., Nielsen, F. H., Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 123: 19391951.
  • 23
    Meyers, C. Y., Kolb, V. M., Dandliker, WB. (1982) Doisynolic acids: potent estrogens with very low affinity for estrogen receptors. Res Commun Chem Pathol Pharmacol. 35: 165168.
  • 24
    Harris, R. B., Martin, RJ. (1984) Specific depletion of body fat in parabiotic partners of tube-fed obese rats. Am J Physiol. 247: R380R386.
  • 25
    Tomanek, R. J., Palmer, P. J., Peiffer, G. L., Schreiber, K. L., Eastham, C. L., Marcus, ML. (1986) Morphometry of canine coronary arteries, arterioles, and capillaries during hypertension and left ventricular hypertrophy. Circ Res. 58: 3846.
  • 26
    Cimini, C. M., Weiss, HR. (1988) Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. Am J Physiol. 255: H1384H1390.
  • 27
    Tcherepanova, I., Puigserver, P., Norris, J. D., Spiegelman, B. M., McDonnell, DP. (2000) Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem. 275: 1630216308.
  • 28
    Wang, X., Kilgore, MW. (2002) Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells. Mol Cell Endocrinol. 194: 123133.
  • 29
    Keller, H., Givel, F., Perroud, M., Wahli, W. (1995) Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol Endocrinol. 9: 794804.
  • 30
    Sporn, M. B., Suh, N., Mangelsdorf, DJ. (2001) Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol Med. 7: 395400.
  • 31
    Crawford, S. E., Qi, C., Misra, P., Stellmach, V., Rao, M. S., Engel, J. D., Zhu, Y., Reddy, JK. (2002) Defects in heart, eye, and megakaryocytes in peroxisome proliferators activator receptor binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem. 277: 35853592.
  • 32
    Sassa, Y., Hata, Y., Aiello, L. P., Taniguchi, Y., Kohno, K., Ishibashi, T. (2004) Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3. Diabetes 53: 12221229.
  • 33
    Jozkowicz, A., Dulak, J., Piatkowska, E., Placha, W., Dembinska-Kiec, A. (2000) Ligands of peroxisome proliferator-activated receptor gamma increase the generation of vascular endothelial cell growth factor in vascular smooth muscle cells and in macrophages. Acta Biochim Pol. 47: 11471157.