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Potential Role of Interleukin-18 in Liver Disease Associated with Insulin Resistance
Article first published online: 6 SEP 2012
2005 North American Association for the Study of Obesity (NAASO)
Volume 13, Issue 11, pages 1925–1931, November 2005
How to Cite
López-Bermejo, A., Bosch, M., Recasens, M., Biarnés, J., Esteve, E., Casamitjana, R., Vendrell, J., Ricart, W. and Fernández-Real, J.-M. (2005), Potential Role of Interleukin-18 in Liver Disease Associated with Insulin Resistance. Obesity Research, 13: 1925–1931. doi: 10.1038/oby.2005.237
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review March 08, 2005; Accepted in final form August 19, 2005
- fatty liver disease;
- alanine aminotransferase;
- aspartate aminotransferase;
Objective: Interleukin (IL)-18 has been associated with obesity and insulin resistance, both risk factors for the development of liver disease, but the role of IL-18 in liver disease associated with insulin resistance is presently unknown. We hypothesized that circulating IL-18 would be related to serum concentrations of liver chemistry tests (LCTs) in apparently healthy subjects and wished to study whether this correlation was dependent on insulin sensitivity (SI).
Research Methods and Procedures: One hundred six apparently healthy white men consecutively enrolled in a cross-sectional, population-based study dealing with SI in men were studied, and SI (minimal model analysis), LCTs (colorimetry), and IL-18 serum concentrations (immunoassay) were assessed.
Results: Compared with subjects in the lowest quartile for serum IL-18, subjects in the highest quartile exhibited increased serum triglycerides and decreased SI, in addition to higher serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (all p < 0.05). The direct association between both ALT and AST and IL-18 was further confirmed by examining the distribution of serum IL-18 by quartiles of ALT and AST. Subjects in the highest quartile for serum ALT and AST had higher IL-18 concentrations compared with subjects in the lowest quartile for these LCTs (both p = 0.01). In multiple regression analysis, IL-18, but not SI, was an independent predictor of serum concentrations of ALT and AST, explaining 7% and 4% of their variance, respectively.
Discussion: In summary, IL-18 serum concentrations are associated in apparently healthy humans with plasma concentrations of various LCTs. IL-18 could contribute to the development of liver disease associated with insulin resistance.