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Heritability of Body Composition Measured by DXA in the Diabetes Heart Study
Article first published online: 6 SEP 2012
2005 North American Association for the Study of Obesity (NAASO)
Volume 13, Issue 2, pages 312–319, February 2005
How to Cite
Hsu, F.-C., Lenchik, L., Nicklas, B. J., Lohman, K., Register, T. C., Mychaleckyj, J., Langefeld, C. D., Freedman, B. I., Bowden, D. W. and Carr, J. J. (2005), Heritability of Body Composition Measured by DXA in the Diabetes Heart Study. Obesity Research, 13: 312–319. doi: 10.1038/oby.2005.42
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review December 24, 2003; Accepted in final form December 09, 2004
- body composition;
- type 2 diabetes;
Objective: The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS).
Research Methods and Procedures: Participants were 292 women and 262 men (age, 38 to 86 years; BMI, 17 to 57 kg/m2) from 244 families. There were 492 white and 49 African-American sibling pairs. DXA measurements of percentage fat mass (FM), whole body FM, and lean mass (LM), as well as regional measurements of trunk fat mass (TFM) and appendicular lean mass (ALM), were obtained. Heritability of FM, LM, and BMI were estimated using Sequential Oligogenic Linkage Analysis Routines.
Results: After adjusting for age, gender, ethnicity, and height, the heritability estimates of various compositional attributes were %FM = 0.64, whole body FM = 0.71, TFM = 0.63, whole body LM = 0.60, ALM = 0.66, and BMI = 0.64 (all p < 0.0001). Additional adjustment for diabetes status, smoking, dietary intake, and physical activity resulted in only minor changes in the heritability estimates (ĥ2 = 0.63 to 0.72, all p < 0.0001). Furthermore, heritability of TFM after additional adjustment for whole body FM was significant (ĥ2 = 0.55, p < 0.0001), and heritability of ALM after additional adjustment for whole body LM was also significant (ĥ2 = 0.51, p < 0.0001).
Discussion: These data suggest that FM and LM measured by DXA are highly heritable and can be effectively used in designing linkage studies to locate genes governing body composition. In addition, regional distribution of FM and LM may be genetically determined.