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Knee Structural Alteration and BMI: A Cross-sectional Study
Article first published online: 6 SEP 2012
2005 North American Association for the Study of Obesity (NAASO)
Volume 13, Issue 2, pages 350–361, February 2005
How to Cite
Ding, C., Cicuttini, F., Scott, F., Cooley, H. and Jones, G. (2005), Knee Structural Alteration and BMI: A Cross-sectional Study. Obesity Research, 13: 350–361. doi: 10.1038/oby.2005.47
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review March 11, 2004; Accepted in final form December 15, 2004
- cartilage defects;
- bone area
Objective: To describe the associations among BMI, knee cartilage morphology, and bone size in adults.
Research Methods and Procedures: A cross-sectional convenience sample of 372 male and female subjects (mean age, 45 years; range, 26 to 61 years) was studied. Knee articular cartilage defect score (0 to 4) and prevalence (defect score of ≥2), volume, and thickness, as well as bone surface area and/or volume, were determined at the patellar, tibial, and femoral sites using T1-weighted fat-saturation magnetic resonance imaging. Height, weight, BMI, and radiographic osteoarthritis were measured by standard protocols.
Results: In multivariate analysis in the whole group, BMI was significantly associated with knee cartilage defect scores (β: +0.016/kg/m2 to +0.083/kg/m2, all p < 0.05) and prevalence (odds ratio: 1.05 to 1.12/kg/m2, all p < 0.05 except for the lateral tibiofemoral compartment). In addition, BMI was negatively associated with patellar cartilage thickness only (β = −0.021 mm/kg/m2; p = 0.039) and was positively associated with tibial bone area (medial: β = +7.1 mm2/kg/m2, p = 0.001; lateral: β = +3.2 mm2/kg/m2, p = 0.037). Those who were obese also had higher knee cartilage defect severity and prevalence and larger medial tibial bone area but no significant change in cartilage volume or thickness compared with those of normal weight.
Discussion: This study suggests that knee cartilage defects and tibial bone enlargement are the main structural changes associated with increasing BMI particularly in women. Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects.