High-Molecular Weight Adiponectin Isoforms Increase after Biliopancreatic Diversion in Obese Subjects
Article first published online: 6 SEP 2012
2006 North American Association for the Study of Obesity (NAASO)
Volume 14, Issue 9, pages 1511–1514, September 2006
How to Cite
Salani, B., Briatore, L., Andraghetti, G., Adami, G. F., Maggi, D. and Cordera, R. (2006), High-Molecular Weight Adiponectin Isoforms Increase after Biliopancreatic Diversion in Obese Subjects. Obesity, 14: 1511–1514. doi: 10.1038/oby.2006.174
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review December 27, 2005, Accepted in final from June 30, 2006
- bariatric surgery;
- biliopancreatic diversion;
- weight loss;
- light-molecular weight adiponectin
Objective: Our objective was to test the effect of biliopancreatic diversion (BDP) in adiponectin multimerization. Adiponectin, the major protein secreted by adipose tissue, circulates in plasma in different isoforms. The most clinically relevant oligomers are high-molecular weight (HMW) multimers and low-molecular weight (LMW) trimers. Contrasting data on the effect of weight loss on adiponectin isoforms have been reported.
Research Methods and Procedures: We measured total plasma adiponectin and HMW and LMW adiponectin oligomers (by Western blot analysis) before and 1 month after BPD, in 18 severely obese subjects.
Results: One month after BPD, body weight decreased ∼11%. Total adiponectin showed significant increase after BPD. In addition, we found a significant increase in HMW (percentage) adiponectin oligomers. We found a significant inverse correlation between HMW (percentage) and BMI before and after BPD. Homeostasis model of assessment-insulin resistance decreased significantly after the BPD, without any significant correlation with total serum adiponectin and adiponectin oligomers.
Discussion: A moderate weight loss after BPD increases total and HMW adiponectin oligomers. The significant correlation between BMI and HMW (percentage) adiponectin oligomers but not between BMI and total adiponectin might indicate a role of body fat mass in regulation of adiponectin multimerization. These data suggest that HMW oligomers represent a very sensitive parameter to short-term BMI changes after BPD.