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  • 1
    Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Accessed June 18, 2002) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Available at http:www.nhlbi.nih.govguidelinescholesterol.
  • 2
    Ford, E. S., Giles, W. H., Dietz, WH. (2002) Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Examination Survey. JAMA. 287: 356359.
  • 3
    Ford, E. S., Giles, W. H., Mokdad, AH. (2004) Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care. 27: 24442449.
  • 4
    Reaven, GM. (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 37: 15951607.
  • 5
    Vague, J. (1956) The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr. 4: 2034.
  • 6
    Albrink, M. J., Meigs, MW. (1964) Interrelationship between skinfold thickness, serum lipids, and blood sugar in normal men. Am J Clin Nutr. 15: 255261.
  • 7
    Reaven, G. M., Lerner, R. L., Stern, M. P., Farquhar, JW. (1967) Role of insulin in endogenous hypertriglyceridemia. J Clin Invest. 46: 17561767.
  • 8
    World Health Organization (1999) Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus. Report of a WHO Consultation. World Health Organization: Geneva, Switzerland.
  • 9
    National Diabetes Data Group (1995) Diabetes in America. 2nd ed. National Institutes of Health: Washington, DC.
  • 10
    Stamler, J., Vaccaro, O., Neaton, J. D., Wentworth, D. (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care. 16: 434444.
  • 11
    Haffner, S. M., Lehto, S., Rönnemma, T., Pyörälä, K., Laakso, M. (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 339: 229234.
  • 12
    Eschwège, E., Richard, J. L., Thibult, N., et al (1995) Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels. The Paris Prospective Study, ten years later. Horm Metab Res. 17: 4146.
  • 13
    The DECODE Study Group, on behalf of the European Diabetes Epidemiology Group (2001) Glucose tolerance and cardiovascular mortality. Comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med. 161: 397404.
  • 14
    Saydah, S. H., Loria, C. M., Eberhardt, M. S., Brancati, FL. (2001) Subclinical states of glucose intolerance and risk of death in the US. Diabetes Care. 24: 447453.
  • 15
    Isomaa, B., Almgren, P., Tuomi, T., et al (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 24: 683689.
  • 16
    Lakka, H. M., Laaksonen, D. E., Lakka, T. A., et al (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 288: 27092716.
  • 17
    Hunt, K. J., Resendez, R. G., Williams, K., Haffner, S. M., Stern, M. P., San Antonio Heart Study (2004) National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardiovascular mortality in the San Antonio Heart Study. Circulation. 110: 12511257.
  • 18
    Resnick, H. E., Jones, K., Ruotolo, G., et al (2003) Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease in nondiabetic American Indians: the Strong Heart Study. Diabetes Care. 26: 861867.
  • 19
    Ford, ES. (2003) The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. Atherosclerosis. 173: 309314.
  • 20
    Stern, M. P., Williams, K., Gonzalez-Villalpando, C., Hunt, K. J., Haffner, SM. (2004) Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care. 27: 26762681.
  • 21
    Siegel, R. D., Cupples, A., Schaefer, E. J., Wilson, PWF. (1996) Lipoproteins, apolipoproteins, and low-density lipoprotein size among diabetics in the Framingham Offspring Study. Metabolism. 45: 12671272.
  • 22
    Davis, RA. (1999) Cell and molecular biology of the assembly and secretion of apolipoprotein B-containing lipoproteins by the liver. Biochim Biophys Acta. 1440: 131.
  • 23
    Olofsson, S. O., Stillemark-Billton, P., Asp, L. (2000) Intracellular assembly of VLDL: two major steps in separate cell compartments. Trends Cardiovasc Med. 10: 338345.
  • 24
    Fisher, E. A., Ginsberg, HN. (2002) Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J Biol Chem. 277: 1737717380.
  • 25
    Hussain, M. M., Iqbal, J., Anwar, K., Rava, P., Dai, K. (2003) Microsomal triglyceride transfer protein: a multifunctional protein. Front Biosci. 8: S500S506.
  • 26
    Ginsberg, HN. (2000) Insulin resistance and cardiovascular disease. J Clin Invest. 106: 453458.
  • 27
    Barter, P. J., Nestel, PJ. (1973) Precursors of plasma triglyceride fatty acids in obesity. Metabolism. 22: 779783.
  • 28
    Kissebah, A. H., Alfarsi, S., Adams, P. W., Wynn, V. (1976) Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man. Diabetologia. 12: 563571.
  • 29
    Lewis, GF. (1999) Fatty acid regulation of very low density lipoprotein (VLDL) production. Curr Opin Lipidol. 10: 475477.
  • 30
    Zhang, Y., Ono-Hernandez, A., Ko, C., Yasunaga, K., Huang, L. S., Ginsberg, HN. (2004) Regulation of hepatic lipoprotein assembly and secretion by the availability of fatty acids. I: Differential responses to the delivery of fatty acids via albumin or remnant-like emulsion particles. J Biol Chem. 279: 1936219374.
  • 31
    Siri, P., Candela, N., Ko, C., et al (2001) Post-transcriptional stimulation of the assembly and secretion of triglyceride-rich apolipoproteinB-lipoproteins in a mouse with selective deficiency of brown adipose tissue, obesity and insulin resistance. J Biol Chem. 276: 4606446072.
  • 32
    Taghibiglou, C., Carpentier, A., Van Iderstine, S. C., et al (2000) Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J Biol Chem. 275: 84168425.
  • 33
    Haemmerle, G., Zimmermann, R., Strauss, J. G., et al (2002) Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. J Biol Chem. 277: 1294612952.
  • 34
    Basu, A., Basu, R., Shah, P., Vella, A., Rizza, R. A., Jensen, MD. (2001) Systemic and regional free fatty acid metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab. 280: E1000E1006.
  • 35
    Hotamisligil, G. S., Shargill, N. S., Spiegelman, BM. (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 259: 8791.
  • 36
    Steppan, C. M., Bailey, S. T., Bhat, S., et al (2001) The hormone resistin links obesity to diabetes. Nature. 409: 307312.
  • 37
    Pajvani, U. B., Scherer, PE. (2003) Adiponectin: systemic contributor to insulin sensitivity. Curr Diab Rep. 3: 207213.
  • 38
    Craig, W. Y., Nutik, R., Cooper, AD. (1988) Regulation of apoprotein synthesis and secretion in the human hepatoma Hep G2. The effect of exogenous lipoprotein. J Biol Chem. 263: 1388013890.
  • 39
    Cohn, J. S., Wagner, D. A., Cohn, S. D., Millar, J. S., Schaefer, EJ. (1990) Measurement of very low density and low density lipoprotein apolipoprotein (Apo) B-100 and high density lipoprotein Apo A-I production in human subjects using deuterated leucine. Effect of fasting and feeding. J Clin Invest. 85: 804811.
  • 40
    Diraison, F., Moulin, P., Beylot, M. (2003) Contribution of hepatic de novo lipogenesis and reesterification of plasma non-esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 29: 478485.
  • 41
    Schwarz, J. M., Linfoot, P., Dare, D., Aghajanian, K. (2003) Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr. 77: 4350.
  • 42
    Hellerstein, MK. (1999) De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr. 53: S53S65.
  • 43
    Horton, J. D., Goldstein, J. L., Brown, MS. (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 109: 11251131.
  • 44
    Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S., Goldstein, JL. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell. 6: 7786.
  • 45
    Matsusue, K., Haluzik, M., Lambert, G., et al (2003) Liver-specific disruption of PPARg in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest. 111: 737747.
  • 46
    Sparks, J. D., Sparks, CE. (1994) Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochim Biophys Acta. 1215: 932.
  • 47
    Taghibiglou, C., Rashid-Kolvear, F., Van Iderstine, S. C., et al (2002) Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem. 277: 793803.
  • 48
    Pan, M., Cederbaum, A. I., Zhang, Y-L, Ginsberg, H. N., Williams, K. J., Fisher, EA. (2004) Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest. 13: 12771288.
  • 49
    Lewis, G. F., Uffelman, K. D., Szeto, L. W., Steiner, G. (1993) Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes. 42: 833842.
  • 50
    Malmstrom, R., Packard, C. J., Caslake, M., et al (1997) Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM. Diabetologia. 40: 454462.
  • 51
    Taghibiglou, C., Rashid-Kolvear, F., Van Iderstine, S. C., et al (2002) Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem. 277: 793803.
  • 52
    Bourgeois, C. S., Wiggins, D., Hems, R., Gibbons, GF. (1995) VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulin. Am J Physiol. 269: E208E215.
  • 53
    Angelico, F., Del Ben, M., Conti, R., et al (2003) Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. J Gastroenterol Hepatol. 18: 588594.
  • 54
    Austin, M. A., Krauss, RM. (1995) LDL density and atherosclerosis. JAMA. 273: 115.
  • 55
    Horowitz, B. S., Goldberg, I. J., Merab, J., Vanni, T., Ramakrishnan, R., Ginsberg, HN. (1993) Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol. J Clin Invest. 91: 17431760.
  • 56
    Chen, J., Wildman, R. P., Hamm, L. L., et al (2004) Association between inflammation and insulin resistance in u.s. Nondiabetic adults: results from the third national health and nutrition examination survey. Diabetes Care. 27: 29602965.
  • 57
    Wellen, K. E., Hotamisligil, GS. (2003) Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 112: 17851788.
  • 58
    Kershaw, E. E., Flier, JS. (2004) Adipose tissue as an endocrine organ. J Clin Endo and Metab. 89: 25482556.
  • 59
    Nawrocki, A. R., Scherer, PE. (2004) The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation. Curr Opin Pharmacol. 4: 281289.
  • 60
    Uysal, K. T., Wiesbrock, S. M., Marino, M. W., Hotamisligil, GS. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 9. 389: 610614.
  • 61
    Nonogaki, K., Fuller, G. M., Fuentes, N. L., et al (1995) Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinol. 136: 21432149.
  • 62
    Weisberg, S., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., Ferrante, AW. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 112: 17961808.
  • 63
    Xu, H., Barnes, G. T., Yang, Q., et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 112: 18211830.