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Fat and Energy Partitioning: Longitudinal Observations in Leptin-treated Adults Homozygous for a Lep Mutation
Article first published online: 6 SEP 2012
2006 North American Association for the Study of Obesity (NAASO)
Volume 14, Issue 2, pages 258–265, February 2006
How to Cite
Heymsfield, S. B., Fong, T. M., Gantz, I. and Erondu, N. (2006), Fat and Energy Partitioning: Longitudinal Observations in Leptin-treated Adults Homozygous for a Lep Mutation. Obesity, 14: 258–265. doi: 10.1038/oby.2006.33
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review April 26, 2005; Accepted in final form December 02, 2005
- body composition;
- recombinant human leptin;
- nutritional assessment;
- percent body fat;
Objective: Partitioning of body energy content in the aleptinemic ob/ob mouse differs from that in wild-type mice, but it is not known whether parallel differences exist between humans with leptin (Lep) gene mutations and healthy adults. The objective of this study was to evaluate body composition in three leptin-treated Turkish adults homozygous for a missense mutation (CT substitution at codon 105 resulting in ArgTrp) of Lep.
Research Methods and Procedures: Subjects, one male and two female Turkish family members, were evaluated at baseline and treated for 18 months with r-MetHuLeptin. Patient data (fat mass, energy content) were compared with adult sex-specific predicted values (adjusted for weight, height, and age) derived in healthy control subjects.
Results: Weight loss with leptin treatment was substantial, ranging from 43.9% to 52.1%. At baseline and with leptin treatment, the two women had a fat mass and energy content similar (±12%) to predicted values. Baseline fat and energy content in the male patient was high compared with predicted values (e.g., fat +33%) but approached and reached normal values (e.g., fat, +2%) after 18 months of leptin therapy.
Discussion: Adult women with Lep mutations had body composition similar to normal women at baseline and with leptin treatment. In contrast, the man with a Lep mutation had high body fat in the untreated state but a normal male phenotype with leptin administration, possibly secondary to androgenic fat partitioning effects. Fat and energy partitioning can, thus, be quantitatively assessed and linked with potential hormonal mechanisms in humans with inherited disturbances in energy regulation.