Left Ventricular Mass and +276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene in Uncomplicated Obesity

Authors

  • Gianluca Iacobellis,

    1. Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy.
    Search for more papers by this author
  • Antonio Petrone,

    1. Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy.
    Search for more papers by this author
  • Frida Leonetti,

    1. Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy.
    Search for more papers by this author
  • Raffaella Buzzetti

    Corresponding author
    1. Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy.
      McMaster University, Hamilton General Hospital, Cardiovascular Obesity Research & Management, 237 Barton Street East, Hamilton, Ontario, L8L 2X2 Canada. E-mail: gianluca@ccc.mcmaster.ca
    Search for more papers by this author

  • The costs of publication of this article were defrayed, in part, by the payment of page charges. This article must, therefore, be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

McMaster University, Hamilton General Hospital, Cardiovascular Obesity Research & Management, 237 Barton Street East, Hamilton, Ontario, L8L 2X2 Canada. E-mail: gianluca@ccc.mcmaster.ca

Abstract

The single nucleotide polymorphism at position 276 in the adiponectin gene (APM1/ACDC +276 G>T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We sought to evaluate whether +276 G>T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height2.7), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 ± 10.2 years; BMI, 38.6 ± 9.1 kg/m2). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese subjects with the APM1/ACDC +276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T genotype. G/G uncomplicated obese subjects showed significant higher LVM/body surface area and LVM/height2.7 (within the normal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.

Ancillary