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Left Ventricular Mass and +276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene in Uncomplicated Obesity
Article first published online: 6 SEP 2012
2006 North American Association for the Study of Obesity (NAASO)
Volume 14, Issue 3, pages 368–372, March 2006
How to Cite
Iacobellis, G., Petrone, A., Leonetti, F. and Buzzetti, R. (2006), Left Ventricular Mass and +276 G/G Single Nucleotide Polymorphism of the Adiponectin Gene in Uncomplicated Obesity. Obesity, 14: 368–372. doi: 10.1038/oby.2006.48
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review March 21, 2005; Accepted in final form December 21, 2005
- adiponectin gene;
- left ventricular mass;
- uncomplicated obesity
The single nucleotide polymorphism at position 276 in the adiponectin gene (APM1/ACDC +276 G>T) and left ventricular mass (LVM) have been associated with increased cardiovascular risk. We sought to evaluate whether +276 G>T variants in the adiponectin gene are correlated with LVM in uncomplicated obese subjects. APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height2.7), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 ± 10.2 years; BMI, 38.6 ± 9.1 kg/m2). Forty lean subjects formed the control group for LVM evaluation. We found 23 (37%) uncomplicated obese subjects with the APM1/ACDC +276 G/G genotype, 25 (40%) with the G/T genotype, and 14 (23%) with the T/T genotype. G/G uncomplicated obese subjects showed significant higher LVM/body surface area and LVM/height2.7 (within the normal range in the majority of them) than uncomplicated obese subjects carrying the G/T and T/T genotypes (p < 0.01 and p < 0.05, respectively). This study showed that LVM is significantly higher in uncomplicated obese subjects carrying the G/G genotype at position 276 of the human adiponectin gene.