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Lack of Association of Glutamate Decarboxylase 2 Gene Polymorphisms with Severe Obesity in Utah
Article first published online: 6 SEP 2012
2006 North American Association for the Study of Obesity (NAASO)
Volume 14, Issue 4, pages 650–655, April 2006
How to Cite
Hunt, S. C., Xin, Y., Wu, L. L., Hopkins, P. N. and Adams, T. D. (2006), Lack of Association of Glutamate Decarboxylase 2 Gene Polymorphisms with Severe Obesity in Utah. Obesity, 14: 650–655. doi: 10.1038/oby.2006.73
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review June 01, 2005; Accepted in final form January 24, 2006
- glutamate decarboxylase 2 gene;
- severe obesity
Three polymorphisms of the glutamate decarboxylase 2 gene, which encodes the glutamic acid decarboxylase enzyme, have been associated with severe obesity in a large French cohort. One of these polymorphisms was shown to have functional consequences on promoter expression. Another polymorphism was associated with insulin levels and secretion. These associations were examined in 855 severely obese Utah subjects (mean BMI = 48 kg/m2) and a normal-weight and normoglycemic subset (N = 130, mean BMI = 22 kg/m2) of a random sample of the Utah population (N = 462). Comparisons of the normal-weight random group with the severely obese group did not result in significant genotype or allele frequency differences for any of the three polymorphisms, C61450A, T83897A, or A-243G (all p ≥ 0.18). Haplotypes were also not related to severe obesity (p = 0.10). None of the polymorphisms was significantly related to fasting glucose, insulin levels, or homeostasis model assessment insulin resistance or secretion indices. This study of normal-weight and severely obese subjects from Utah does not provide evidence for involvement of the three genotyped polymorphisms in the glutamate decarboxylase 2 gene with obesity or with insulin- and glucose-related measures associated with obesity.