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Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in Asians
Article first published online: 6 SEP 2012
2006 North American Association for the Study of Obesity (NAASO)
Volume 14, Issue 4, pages 656–661, April 2006
How to Cite
Shen, H., Qi, L., Tai, E. S., Chew, S. K., Tan, C. E. and Ordovas, J. M. (2006), Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in Asians. Obesity, 14: 656–661. doi: 10.1038/oby.2006.74
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received for review July 20, 2005; Accepted in final form January 24, 2006
- uncoupling protein 2;
- metabolic syndrome;
A polymorphism in the promoter region of uncoupling protein 2 gene −866G/A has been associated with its expression levels in adipose tissue, the risk of obesity, and metabolic abnormalities. Our purpose was to examine the associations of −866G/A with body fat and the risk of metabolic syndrome in a random sample of 4018 Asians (1858 men and 2160 women) from three ethnic groups (Chinese, Malay, and Indian). The minor allele frequency of −866G/A polymorphism in South Asians was similar to that in whites. After adjustment for covariates including age, cigarette smoking, and physical activity, the −866A/A genotype was associated with higher waist-to-hip ratio as compared with the wild-type genotype in Chinese and Indian men (p = 0.018 and p = 0.046, respectively). Moreover, Indian men with −866A/A genotype had a significantly increased risk of metabolic syndrome as compared with those homozygous for the wild-type (odds ratio, 2.66; 95% confidence interval, 1.21 to 5.88; p = 0.015). Such a risk was mainly caused by the excess presence of hypertriglyceridemia and central obesity. Our findings indicate that the uncoupling protein 2 gene −866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men.