• 1
    Fleury, C., Neverova, M., Collins, S., et al (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 15: 269272.
  • 2
    Krauss, S., Zhang, C. Y., Lowell, BB. (2002) A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA 99: 118122.
  • 3
    Chan, C. B., Saleh, M. C., Koshkin, V., Wheeler, MB. (2004) Uncoupling protein 2 and islet function. Diabetes 53: (Suppl 1), S136S142.
  • 4
    Himms-Hagen, J., Harper, ME. (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 226: 7884.
  • 5
    Oberkofler, H., Liu, Y. M., Esterbauer, H., Hell, E., Krempler, F., Patsch, W. (1998) Uncoupling protein-2 gene: reduced mRNA expression in intraperitoneal adipose tissue of obese humans. Diabetologia 41: 940946.
  • 6
    Esterbauer, H., Schneitler, C., Oberkofler, H., et al (2001) A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet. 28: 178183.
  • 7
    Ji, Q., Ikegami, H., Fujisawa, T., et al (2004) A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens 22: 97102.
  • 8
    Reis, A. F., Dubois-Laforgue, D., Bellanne-Chantelot, C., Timsit, J., Velho, G. (2004) A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes. Mol Genet Metab. 82: 339344.
  • 9
    D'Adamo, M., Perego, L., Cardellini, M., et al (2004) The −866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes. Diabetes 53: 19051910.
  • 10
    Krempler, F., Esterbauer, H., Weitgasser, R., et al (2002) A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes 51: 33313335.
  • 11
    Sasahara, M., Nishi, M., Kawashima, H., et al (2004) Uncoupling protein 2 promoter polymorphism −866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 53: 482485.
  • 12
    Wang, H., Chu, W. S., Lu, T., Hasstedt, S. J., Kern, P. A., Elbein, SC. (2004) Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion. Am J Physiol Endocrinol Metab. 286: E1E7.
  • 13
    Dalgaard, L. T., Andersen, G., Larsen, L. H., et al (2003) Mutational analysis of the UCP2 core promoter and relationships of variants with obesity. Obes Res. 11: 14201427.
  • 14
    Björntorp, P. (1992) Regional obesity. Björntorp, P Brodoff, BN eds. Obesity 579586.JB Lippincott Co. Philadelphia, PA.
  • 15
    Pericàs, J., Oliver, P., Guitard, R., Pico, C., Palou, A. (2001) Sexual dimorphism in age-related changes in UCP2 and leptin gene expression in subcutaneous adipose tissue in humans. J Nutr Biochem. 12: 444449.
  • 16
    Rodriguez, A. M., Monjo, M., Roca, P., Palou, A. (2002) Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes. Cell Mol Life Sci. 59: 17141723.
  • 17
    Bulotta, A., Ludovico, O., Coco, A., et al (2005) The common −866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. J Clin Endocrinol Metab. 90: 11761180.
  • 18
    Cutter, J., Tan, B. Y., Chew, SK. (2001) Levels of cardiovascular disease risk factors in Singapore following a national intervention programme. Bull World Health Organ 79: 908915.
  • 19
    Tai, E. S., Ordovas, J. M., Corella, D., et al (2003) The TaqIB and −629C>A polymorphisms at the cholesteryl ester transfer protein locus: associations with lipid levels in a multiethnic population. The 1998 Singapore National Health Survey. Clin Genet. 63: 1930.
  • 20
    Tan, C. E., Ma, S., Wai, D., Chew, S. K., Tai, ES. (2004) Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care 27: 11821186.