• 1
    Tuomilehto, J., Lindstrom, J., Eriksson, J. G., et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 344: 13431350.
  • 2
    Knowler, W. C., Barrett-Connor, E., Fowler, S. E., et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 346: 393403.
  • 3
    Pan, X. R., Li, G. W., Hu, Y. H., et al. (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20: 537544.
  • 4
    Stevens, V. J., Corrigan, S. A., Obarzanek, E., et al. (1993) Weight loss intervention in Phase 1 of the Trials of Hypertension Prevention: the TOHP Collaborative Research Group. Arch Intern Med. 153: 849858.
  • 5
    Stevens, V. J., Obarzanek, E., Cook, N. R., et al. (2001) Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, Phase II. Ann Intern Med. 134: 111.
  • 6
    Avenell, A., Broom, J., Brown, T. J., et al. (2004) Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol Assess. 8: 1182.
  • 7
    Wood, P. D., Stefanick, M. L., Williams, P. T., Haskell, WL (1991) The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women. N Engl J Med. 325: 461466.
  • 8
    Poobalan, A., Aucott, L., Smith, W. C., et al. (2004) Effects of weight loss in overweight/obese individuals and long-term lipid outcomes: a systematic review. Obes Rev. 5: 4350.
  • 9
    Wadden, T. A., Sternberg, J. A., Letizia, K. A., Stunkard, A. J., Foster, GD (1989) Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective. Int J Obes. 13 (suppl): 3946.
  • 10
    Ditschuneit, H. H., Flechtner-Mors, M., Johnson, T. D., Adler, G. (1999) Metabolic and weight-loss effects of a long-term dietary intervention in obese patients. Am J Clin Nutr. 69: 198204.
  • 11
    Heymsfield, S. B., van Mierlo, C. A., van der Knaap, H. C., Heo, M., Frier, HI (2003) Weight management using a meal replacement strategy: meta and pooling analysis from six studies. Int J Obes Relat Metab Disord. 27: 537549.
  • 12
    Keogh, J. B., Clifton, PM (2005) The role of meal replacements in obesity treatment. Obes Rev. 6: 229234.
  • 13
    Ditschuneit, H. H., Flechtner-Mors, M. (2001) Value of structured meals for weight management: risk factors and long-term weight maintenance. Obes Res. 9 (Suppl 4), 284289.
  • 14
    Rothacker, Quinn D. (2000) Five-year self-management of weight using meal replacements: comparison with matched controls in rural Wisconsin. Nutrition 16: 344348.
  • 15
    Hansen, D. L., Toubro, S., Stock, M. J., Macdonald, I. A., Astrup, A. (1998) Thermogenic effects of sibutramine in humans. Am J Clin Nutr. 68: 11801186.
  • 16
    Walsh, K. M., Leen, E., Lean, ME (1999) The effect of sibutramine on resting energy expenditure and adrenaline-induced thermogenesis in obese females. Int J Obes Relat Metab Disord. 23: 10091015.
  • 17
    James, W. P. T., Astrup, A., Finer, N., et al. (2000) Effect of sibutramine on weight maintenance after weight loss: a randomized trial (STORM). Lancet 356: 21192125.
  • 18
    Apfelbaum, M., Vague, P., Ziegler, O., Hanotin, C., Thomas, F., Leutenegger, E. (1999) Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine. Am J Med. 106: 179184.
  • 19
    SAS Institute, Inc. (1990) SAS Users Guide: SAS Procedures Guide SAS Institute, Inc. Cary, NC..
  • 20
    Hauner, H., Meier, M., Wendland, G., et al. (2004) Weight reduction by sibutramine in obese subjects in primary care medicine: the SAT study. Exp Clin Endocrinol Diabetes 112: 201207.
  • 21
    International Diabetes Federation. Consensus Worldwide Definition of the Metabolic Syndrome. http:www.idf.orgwebdatadocsMetSdefFINAL.pdf (Accessed December 21, 2005).
  • 22
    Wing, R. R., Jeffery, R. W., Burton, L. R., Thorson, C., Nissinoff, K. S., Baxter, JE (1996) Food provision vs. structured meal plans in the behavioral treatment of obesity. Int J Obes Relat Metab Disord. 20: 5662.
  • 23
    Ryan, D. H., Espeland, M. A., Foster, G. D., et al. (2003) Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials 24: 610628.