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Single Nucleotide Polymorphisms of the MCHR1 Gene Do Not Affect Metabolism in Humans
Version of Record online: 6 SEP 2012
2007 North American Association for the Study of Obesity (NAASO)
Volume 15, Issue 12, pages 2902–2907, December 2007
How to Cite
Rutanen, J., Pihlajamäki, J., Vänttinen, M., Salmenniemi, U., Ruotsalainen, E., Kuulasmaa, T., Kainulainen, S., Kuusisto, J. and Laakso, M. (2007), Single Nucleotide Polymorphisms of the MCHR1 Gene Do Not Affect Metabolism in Humans. Obesity, 15: 2902–2907. doi: 10.1038/oby.2007.345
- Issue online: 6 SEP 2012
- Version of Record online: 6 SEP 2012
- Received for review January 12, 2007, Accepted in final from May 07, 2007
- energy expenditure;
- insulin sensitivity;
- central nervous system
Melanin concentrating hormone receptor-1 (MCHR1) is a centrally and peripherally expressed receptor that regulates energy expenditure and appetite. Single nucleotide polymorphisms (SNPs) of the MCHR1 gene have been previously associated with obesity, but the results are inconsistent among different populations. This study was performed to determine whether SNPs of MCHR1 affect glucose and energy metabolism. We screened six SNPs of MCHR1 in a cross-sectional study of 217 middle-age, non-diabetic Finnish subjects who were offspring of type 2 diabetic patients. Insulin secretion was evaluated by an intravenous glucose tolerance test and insulin sensitivity and energy metabolism by the hyperinsulinemic euglycemic clamp and indirect calorimetry. SNPs of MCHR1 were not associated with BMI, waist circumference, subcutaneous or intra-abdominal fat area, glucose tolerance, first-phase insulin release, insulin sensitivity, or energy metabolism. One SNP, which was in >0.50 linkage disequilibrium with the other five SNPs, was also screened in 1455 unrelated Finnish middle-age subjects in a population-based study. No differences in BMI, waist circumference, or glucose or insulin levels in an oral glucose tolerance test among the genotypes were found. In conclusion, SNPs of MCHR1 did not have effects on metabolic variables in humans.