• 1
    Sharma, A. M., Chetty, VT (2005) Obesity, hypertension and insulin resistance. Acta Diabetol. 42 (Suppl 1): S3S8.
  • 2
    Abate, N. (2000) Obesity and cardiovascular disease: pathogenetic role of the metabolic syndrome and therapeutic implications. J Diabetes Complications 14: 154174.
  • 3
    Lebovitz, HE (2003) The relationship of obesity to the metabolic syndrome. Int J Clin Pract Suppl. 134: 1827.
  • 4
    Urakawa, H., Katsuki, A., Sumida, Y., et al (2003) Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab. 88: 46734676.
  • 5
    Couillard, C., Ruel, G., Archer, W. R., et al (2005) Circulating levels of oxidative stress markers and endothelial adhesion molecules in men with abdominal obesity. J Clin Endocrinol Metab. 90: 64546459.
  • 6
    Furukawa, S., Fujita, T., Shimabukuro, M., et al (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 114: 17521761.
  • 7
    Mertens, I., Van Gaal, LF (2005) Visceral fat as a determinant of fibrinolysis and hemostasis. Semin Vasc Med. 5: 4855.
  • 8
    Park, K. G., Park, K. S., Kim, M. J., et al (2004) Relationship between serum adiponectin and leptin concentrations and body fat distribution. Diabetes Res Clin Pract. 63: 135142.
  • 9
    Piche, M. E., Lemieux, S., Weisnagel, S. J., Corneau, L., Nadeau, A., Bergeron, J. (2005) Relation of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and fibrinogen to abdominal adipose tissue, blood pressure, and cholesterol and triglyceride levels in healthy postmenopausal women. Am J Cardiol. 96: 9297.
  • 10
    Aldhahi, W., Hamdy, O. (2003) Adipokines, inflammation, and the endothelium in diabetes. Curr Diab Rep. 3: 293298.
  • 11
    Soares, A. F., Guichardant, M., Cozzone, D., et al (2005) Effects of oxidative stress on adiponectin secretion and lactate production in 3T3–L1 adipocytes. Free Radic Biol Med. 38: 882889.
  • 12
    Quinn, L. S., Strait-Bodey, L., Anderson, B. G., Argiles, J. M., Havel, PJ (2005) Interleukin-15 stimulates adiponectin secretion by 3T3–L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway. Cell Biol Int. 29: 449457.
  • 13
    Lin, Y., Berg, A. H., Iyengar, P., et al (2005) The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem. 280: 46174626.
  • 14
    Ozcan, U., Cao, Q., Yilmaz, E., et al (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457461.
  • 15
    Kobayashi, K. (2005) Adipokines: therapeutic targets for metabolic syndrome. Curr Drug Targets 6: 525529.
  • 16
    Zemel, MB (2005) The role of dairy foods in weight management. J Am Coll Nutr. 24 (Suppl 6): 537S546S.
  • 17
    Zemel, MB (2004) Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr. 79: 907S912S.
  • 18
    Sun, X., Zemel, MB (2006) Dietary calcium regulates ROS production in aP2-agouti transgenic mice on high-fat/high-sucrose diets. Int J Obesity (Lond). 30: 13411346.
  • 19
    Reeves, PG (1997) Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 127: 838S841S.
  • 20
    Sun, X., Zemel, MB (2004) Calcium and dairy products inhibit weight and fat regain during ad libitum consumption following energy restriction in Ap2-agouti transgenic mice. J Nutr. 134: 30543060.
  • 21
    Shi, H., Norman, A. W., Okamura, W. H., Sen, A., Zemel, MB (2001) 1alpha, 25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J. 15: 27512753.
  • 22
    Shi, H., Norman, A. W., Okamura, W. H., Sen, A., Zemel, MB (2002) 1alpha, 25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J. 16: 18081810.
  • 23
    Zemel, M. B., Shi, H., Greer, B., Dirienzo, D., Zemel, PC (2000) Regulation of adiposity by dietary calcium. FASEB J. 14: 11321138.
  • 24
    Zemel, M. B., Richards, J., Milstead, A., Campbell, P. (2005) Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res. 13: 12181225.
  • 25
    Thompson, W. G., Holdman, Rostad N., Janzow, D. J., Slezak, J. M., Morris, K. L., Zemel, MB (2005) Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. Obes Res. 13: 13441353.
  • 26
    Zemel, M. B., Thompson, W., Milstead, A., Morris, K., Campbell, P. (2004) Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res. 12: 582590.
  • 27
    Zemel, M. B., Richards, J., Mathis, S., Milstead, A., Gebhardt, L., Silva, E. (2005) Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond). 29: 391397.
  • 28
    Lee, Y. H., Pratley, RE (2005) The evolving role of inflammation in obesity and the metabolic syndrome. Curr Diab Rep. 5: 7075.
  • 29
    Valle, M., Martos, R., Gascon, F., Canete, R., Zafra, M. A., Morales, R. (2005) Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab. 31: 5562.
  • 30
    Clement, K., Viguerie, N., Poitou, C., et al (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J. 18: 16571669.
  • 31
    Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., et al (2004) The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 14: 589600.
  • 32
    Fried, S. K., Bunkin, D. A., Greenberg, AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 83: 847850.
  • 33
    Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P., Bahouth, SW (2004) Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145: 22732282.
  • 34
    Hotamisligil, G. S., Murray, D. L., Choy, L. N., Spiegelman, BM (1994) Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A 91: 48544858.
  • 35
    Ofei, F., Hurel, S., Newkirk, J., Sopwith, M., Taylor, R. (1996) Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 45: 881885.
  • 36
    Busquets, S., Figueras, M. T., Meijsing, S., et al (2005) Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect. Int J Mol Med. 16: 471476.
  • 37
    Carbo, N., Lopez-Soriano, J., Costelli, P., et al (2000) Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br J Cancer 83: 526531.
  • 38
    Alvarez, B., Carbo, N., Lopez-Soriano, J., et al (2002) Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue. Biochim Biophys Acta. 1570: 3337.
  • 39
    Carbó, N., Lopez-Soriano, J., Costelli, P., et al (2001) Interleukin-15 mediates reciprocal regulation of adipose tissue and muscle mass: a potential role in body weight control. Biochim Biophys Acta. 1526: 1724.
  • 40
    Argiles, J. M., Lopez-Soriano, J., Almendro, V., Busquets, S., Lopez-Soriano, FJ (2005) Cross-talk between skeletal muscle and adipose tissue: a link with obesity. Med Res Rev. 25: 4965.
  • 41
    Suzuki, K., Ito, Y., Ochiai, J., et al (2003) Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese. Asian Pac J Cancer Prev. 4: 259266.
  • 42
    Sun, X. C., Zemel, MB (2004) Reactive oxygen species stimulate cell proliferation and down-regulate UCP2 expression in 3T3–L1 adipocytes. Obes Res. 11: A37 (abstr).
  • 43
    Inoguchi, T., Li, P., Umeda, F., et al (2000) High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49: 19391945.
  • 44
    Mahadev, K., Motoshima, H., Wu, X., et al (2004) The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol. 24: 18441854.
  • 45
    Sorescu, D., Weiss, D., Lassegue, B., et al (2002) Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 105: 14291435.
  • 46
    Xu, H., Barnes, G. T., Yang, Q., et al (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 112: 18211830.
  • 47
    Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., Ferrante, AW, Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 112: 17961808.
  • 48
    Wajchenberg, BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev. 21: 697738.
  • 49
    Li, Y., Bujo, H., Takahashi, K., et al (2003) Visceral fat: higher responsiveness of fat mass and gene expression to calorie restriction than subcutaneous fat. Exp Biol Med (Maywood). 228: 11181123.