BMI and Retinal Vascular Caliber in Children

Authors

  • Ning Cheung,

    1. Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    2. Royal Melbourne Hospital, Victoria, Australia
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  • Seang Mei Saw,

    1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    2. Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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  • F.M. Amirul Islam,

    1. Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
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  • Sophie L. Rogers,

    1. Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
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  • Anoop Shankar,

    1. Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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  • Kristin De Haseth,

    1. Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
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  • Paul Mitchell,

    1. Centre for Vision Research, the University of Sydney, New South Wales, Australia.
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  • Tien Yin Wong

    Corresponding author
    1. Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    2. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    3. Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
      Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia. E-mail: twong@unimelb.edu.au
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Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia. E-mail: twong@unimelb.edu.au

Abstract

Objective: In adult populations, changes in retinal vascular caliber have been linked with obesity and metabolic syndrome. We examined the association of BMI and weight with retinal vascular caliber in children.

Research Methods and Procedures: This was a school-based, cross-sectional study of 768 children, 7 to 9 years old, randomly sampled from the Singapore Cohort Study of the Risk Factors for Myopia. Participants had digital retinal photographs. Retinal vascular caliber was measured using a computer-based program and combined to provide average calibers of arterioles and venules in that eye. Weight and height were measured using standardized protocol. These data were used to calculate BMI.

Results: In this population, the mean retinal arteriolar and venular calibers were 156.40 μm [95% confidence interval (CI), 155.44 to 157.36] and 225.43 μm (95% CI, 224.10 to 226.74) respectively. After controlling for age, gender, race, parental monthly income, axial length, birth weight, and birth length, each 3.1 kg/m2 (standard deviation) increase in BMI was associated with a 2.55-μm (95% CI, 1.21 to 3.89; p < 0.001) larger retinal venular caliber. In multivariable analysis, greater weight was also significantly associated with larger retinal venular caliber. BMI and weight were not associated with retinal arteriolar caliber. Height was not significantly associated with retinal arteriolar or venular caliber.

Discussion: Greater BMI and weight are associated with larger retinal venular caliber in healthy children.

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