• 1
    Eckel RH, Krauss RM. American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 1998; 97: 20992100.
  • 2
    Rimm EB, Stampfer MJ, Giovannucci E et al. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol 1995; 141: 11171127.
  • 3
    Mazurek T, Zhang L, Zalewski A et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003; 108: 24602466.
  • 4
    Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 16851695.
  • 5
    Rumberger JA, Simons DB, Fitzpatrick LA, Sheedy PF, Schwartz RS. Oronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study. Circulation 1995; 92: 21572162.
  • 6
    Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 2004; 291: 210215.
  • 7
    Bild DE, Bluemke DA, Burke GL et al. Multi-ethnic study of atherosclerosis: objectives and design. Am J Epidemiol 2002; 156: 871881.
  • 8
    Carr JJ, Nelson JC, Wong ND et al. Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study. Radiology 2005; 234: 3543.
  • 9
    Agatston AS, Janowitz WR, Hildner FJ et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15: 827832.
  • 10
    Detrano RC, Anderson M, Nelson J et al. Coronary calcium measurements: effect of CT scanner type and calcium measure on rescan reproducibility—MESA study. Radiology 2005; 236: 477484.
  • 11
    Bild DE, Detrano R, Peterson D et al. Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 2005; 111: 13131320.
  • 12
    Wheeler GL, Shi R, Beck SR et al. Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families. Invest Radiol 2005; 40: 97101.
  • 13
    Report of the expert committee on the diagnosis, and classification of diabetes, mellitus Diabetes Care, 2003; 26 (Suppl 1):S5S20.
  • 14
    Iacobellis G, Assael F, Ribaudo MC et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 2003; 11: 304310.
  • 15
    Taguchi R, Takasu J, Itani Y et al. Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 2001; 157: 203209.
  • 16
    Roffe C. Ageing of the heart. Br J Biomed Sci 1998; 55: 136148.
  • 17
    Engeli S. Is there a pathophysiological role for perivascular adipocytes?. Am J Physiol Heart Circ Physiol 2005; 289: H1794H1795.
  • 18
    Montani JP, Carroll JF, Dwyer TM et al. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 2004; 28 (Suppl 4):S58S65.
  • 19
    Iacobellis G, Ribaudo MC, Assael F et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003; 88: 51635168.
  • 20
    Poirier P, Giles TD, Bray GA et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006; 113: 898918.
  • 21
    Alexander JK. Obesity and coronary heart disease. Am J Med Sci 2001; 321: 215224.
  • 22
    Seidell JC, Pérusse L, Després JP, Bouchard C. Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: the Quebec Family Study. Am J Clin Nutr 2001; 74: 315321.
  • 23
    Bowden DW, Lange LA, Langefeld CD et al. The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J 2005; 150: 10321038.
  • 24
    Okamoto E, Couse T, De Leon H et al. Perivascular inflammation after balloon angioplasty of porcine coronary arteries. Circulation 2001; 104: 22282235.
  • 25
    Zhang L, Zalewski A, Liu Y et al. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation 2003; 108: 472478.
  • 26
    Miyata K, Shimokawa H, Kandabashi T et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol 2000; 20: 23512358.
  • 27
    Henrichot E, Juge-Aubry CE, Pernin A et al. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis?. Arterioscler Thromb Vasc Biol 2005; 25: 25942599.
  • 28
    Dubrovska G, Verlohren S, Luft FC, Gollasch M. Mechanisms of ADRF release from rat aortic adventitial adipose tissue. Am J Physiol Heart Circ Physiol 2004; 286: H1107H1113.
  • 29
    Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity. Am J Physiol Heart Circ Physiol 2005; 289: H1807H1813.
  • 30
    Ross R. Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340: 115126.
  • 31
    Marchington JM, Mattacks CA, Pond CM. Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties. Comp Biochem Physiol B 1989; 94: 225232.
  • 32
    Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005; 111: 34813488.
  • 33
    Unger RH, Orci L. Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 2002; 1585: 202212.
  • 34
    Fujimoto WY, Bergstrom RW, Boyko EJ et al. Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. Diabetes Care 1999; 22: 18081812.