The first two authors contributed equally to this work.
The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI
Version of Record online: 6 SEP 2012
2009 North American Association for the Study of Obesity (NAASO)
Volume 17, Issue 12, pages 2254–2257, December 2009
How to Cite
Zhao, J., Bradfield, J. P., Li, M., Wang, K., Zhang, H., Kim, C. E., Annaiah, K., Glessner, J. T., Thomas, K., Garris, M., Frackelton, E. C., Otieno, F. G., Shaner, J. L., Smith, R. M., Chiavacci, R. M., Berkowitz, R. I., Hakonarson, H. and Grant, S. F.A. (2009), The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI. Obesity, 17: 2254–2257. doi: 10.1038/oby.2009.159
- Issue online: 6 SEP 2012
- Version of Record online: 6 SEP 2012
- Received 20 February 2009; accepted 22 April 2009
The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. A number of genetic determinants of adult BMI have already been established through genome-wide association (GWA) studies. In this study, we examined 25 single-nucleotide polymorphisms (SNPs) corresponding to 13 previously reported genomic loci in 6,078 children with measures of BMI. Fifteen of these SNPs yielded at least nominally significant association to BMI, representing nine different loci including INSIG2, FTO, MC4R, TMEM18, GNPDA2, NEGR1, BDNF, KCTD15, and 1q25. Other loci revealed no evidence for association, namely at MTCH2, SH2B1, 12q13, and 3q27. For the 15 associated variants, the genotype score explained 1.12% of the total variation for BMI z-score. We conclude that among 13 loci that have been reported to associate with adult BMI, at least nine also contribute to the determination of BMI in childhood as demonstrated by their associations in our pediatric cohort.