You have full text access to this OnlineOpen article

Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Ching-Yu Cheng^1,2,3,
David Reich^4,5,
Josef Coresh^1,6,
Eric Boerwinkle⁷,
Nick Patterson⁵,
Man Li¹,
Kari E. North⁸,
Arti Tandon⁵,
Joan E. Bailey-Wilson²,
James G. Wilson⁹,
W.H. Linda Kao^1,*

Article first published online: 6 SEP 2012

DOI: 10.1038/oby.2009.282

2010 North American Association for the Study of Obesity (NAASO)

Issue

Obesity

Volume 18, Issue 3, pages 563–572, March 2010

Additional Information

How to Cite

Cheng, C.-Y., Reich, D., Coresh, J., Boerwinkle, E., Patterson, N., Li, M., North, K. E., Tandon, A., Bailey-Wilson, J. E., Wilson, J. G. and Kao, W.H. L. (2010), Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Obesity, 18: 563–572. doi: 10.1038/oby.2009.282

Author Information

¹
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
²
Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, Maryland, USA
³
Department of Opthalmology, National Yang Ming University School of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan
⁴
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
⁵
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, USA
⁶
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
⁷
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
⁸
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
⁹
The V.A. Medical Center and the University of Mississippi Medical Center, Jackson, Mississippi, USA

^*(wkao@jhsph.edu)

This article was originally published as Integrative Physiology.

Publication History

Issue published online: 6 SEP 2012
Article first published online: 6 SEP 2012
Received 21 September 2008; accepted 17 July 2009

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (370K)

REFERENCES

1
Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science 1998; 280: 1371–1374.
2
Bouchard C. Genetics of human obesity: recent results from linkage studies. J Nutr 1997; 127: 1887S–1890S.
3
Comuzzie AG, Allison DB. The search for human obesity genes. Science 1998; 280: 1374–1377.
4
Ogden CL, Carroll MD, Curtin LR et al. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006; 295: 1549–1555.
5
Wang Y, Beydoun MA. The obesity epidemic in the United States—gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev 2007; 29: 6–28.
6
Rife DC. Populations of hybrid origin as source material for the detection of linkage. Am J Hum Genet 1954; 6: 26–33.
7
Chakraborty R, Weiss KM. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA 1988; 85: 9119–9123.
8
McKeigue PM. Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet 1997; 60: 188–196.
9
Hoggart CJ, Shriver MD, Kittles RA, Clayton DG, McKeigue PM. Design and analysis of admixture mapping studies. Am J Hum Genet 2004; 74: 965–978.
10
Patterson N, Hattangadi N, Lane B et al. Methods for high-density admixture mapping of disease genes. Am J Hum Genet 2004; 74: 979–1000.
11
Smith MW, Patterson N, Lautenberger JA et al. A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet 2004; 74: 1001–1013.
12
Carlson CS, Eberle MA, Rieder MJ et al. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 2003; 33: 518–521.
13
Reich D, Patterson N, De Jager PL et al. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet 2005; 37: 1113–1118.
14
Freedman ML, Haiman CA, Patterson N et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci USA 2006; 103: 14068–14073.
15
Zhu X, Luke A, Cooper RS et al. Admixture mapping for hypertension loci with genome-scan markers. Nat Genet 2005; 37: 177–181.
16
Reich D, Patterson N, Ramesh V et al. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet 2007; 80: 716–726.
17
Nalls MA, Wilson JG, Patterson NJ et al. Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies. Am J Hum Genet 2008; 82: 81–87.
18
Kao WH, Klag MJ, Meoni LA et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 2008; 40: 1185–1192.
19
Haiman CA, Patterson N, Freedman ML et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet 2007; 39: 638–644.
20
Tang H, Jorgenson E, Gadde M et al. Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Genet 2006; 119: 624–633.
21
Fernández JR, Shriver MD, Beasley TM et al. Association of African genetic admixture with resting metabolic rate and obesity among women. Obes Res 2003; 11: 904–911.
22
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol 1989; 129: 687–702.
- PubMed
23
Ferrario M, Carpenter MA, Chambless LE. Reliability of body fat distribution measurements. The ARIC Study baseline cohort results. Atherosclerosis Risk in Communities Study. Int J Obes Relat Metab Disord 1995; 19: 449–457.
24
Steffes MW, Gross MD, Schreiner PJ et al. Serum adiponectin in young adults—interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study. Ann Epidemiol 2004; 14: 492–498.
25
Bureau of the Census. 1980 Census of population: classified index of industries and occupations. Bureau of the Census: Washington, DC, 1982.
26
Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982; 36: 936–942.
27
Willett WC, Sampson L, Stampfer MJ et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 1985; 122: 51–65.
28
Anderson JT, Jacobs DR Jr, Foster N et al. Scoring systems for evaluating dietary pattern effect on serum cholesterol. Prev Med 1979; 8: 525–537.
29
Hinds DA, Stuve LL, Nilsen GB et al. Whole-genome patterns of common DNA variation in three human populations. Science 2005; 307: 1072–1079.
30
Frazer KA, Ballinger DG, Cox DR et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851–861.
31
Fan JB, Oliphant A, Shen R et al. Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol 2003; 68: 69–78.
32
Deo RC, Patterson N, Tandon A et al. A high-density admixture scan in 1,670 African Americans with hypertension. PLoS Genet 2007; 3: e196.
33
Patterson N, Price AL, Reich D. Population structure and eigenanalysis. PLoS Genet 2006; 2: e190.
34
Price AL, Patterson NJ, Plenge RM et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38: 904–909.
35
Keys A, Anderson JT, Grande F. Prediction of serum-cholesterol responses of man to changes in fats in the diet. Lancet 1957; 273: 959–966.
- CrossRef,
- PubMed,
- CAS
36
Carroll JF, Chiapa AL, Rodriquez M et al. Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity (Silver Spring) 2008; 16: 600–607.
37
Lovejoy JC, de la Bretonne JA, Klemperer M, Tulley R. Abdominal fat distribution and metabolic risk factors: effects of race. Metabolism 1996; 45: 1119–1124.
38
Conway JM, Yanovski SZ, Avila NA, Hubbard VS. Visceral adipose tissue differences in black and white women. Am J Clin Nutr 1995; 61: 765–771.
39
Kanaley JA, Giannopoulou I, Tillapaugh-Fay G, Nappi JS, Ploutz-Snyder LL. Racial differences in subcutaneous and visceral fat distribution in postmenopausal black and white women. Metab Clin Exp 2003; 52: 186–191.
40
Katzmarzyk PT, Pérusse L, Rao DC, Bouchard C. Familial risk of obesity and central adipose tissue distribution in the general Canadian population. Am J Epidemiol 1999; 149: 933–942.
41
Williams RC, Long JC, Hanson RL, Sievers ML, Knowler WC. Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians. Am J Hum Genet 2000; 66: 527–538.
42
Shaffer JR, Kammerer CM, Reich D et al. Genetic markers for ancestry are correlated with body composition traits in older African Americans. Osteoporos Int 2007; 18: 733–741.
43
Reiner AP, Carlson CS, Ziv E et al. Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA Study. Hum Genet 2007; 121: 565–575.
44
Hedley AA, Ogden CL, Johnson CL et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA 2004; 291: 2847–2850.
45
Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889–894.
46
Rotimi CN, Comuzzie AG, Lowe WL et al. The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. Diabetes 1999; 48: 643–644.
47
Comuzzie AG, Hixson JE, Almasy L et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997; 15: 273–276.
48
Hager J, Dina C, Francke S et al. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet 1998; 20: 304–308.
49
Pritchard LE, Turnbull AV, White A. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. J Endocrinol 2002; 172: 411–421.
50
Boston BA, Blaydon KM, Varnerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997; 278: 1641–1644.
51
Baker M, Gaukrodger N, Mayosi BM et al. Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study. Diabetes 2005; 54: 2492–2496.
52
Sutton BS, Langefeld CD, Williams AH et al. Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study. Obes Res 2005; 13: 1491–1498.
53
Feng N, Adler-Wailes D, Elberg J et al. Sequence variants of the POMC gene and their associations with body composition in children. Obes Res 2003; 11: 619–624.

View Full Article with Supporting Information (HTML) Get PDF (370K)

JOURNAL TOOLS

JOURNAL MENU

FIND ISSUES

FIND ARTICLES

GET ACCESS

FOR CONTRIBUTORS

ABOUT THIS JOURNAL

SPECIAL FEATURES

Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Obesity

How to Cite

Author Information

Publication History

ARTICLE TOOLS

REFERENCES

More content like this

JOURNAL TOOLS

JOURNAL MENU

FIND ISSUES

FIND ARTICLES

GET ACCESS

FOR CONTRIBUTORS

ABOUT THIS JOURNAL

SPECIAL FEATURES

Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study

Obesity

How to Cite

Author Information

Publication History

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

REFERENCES

More content like this