• 1
    Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112: 17851788.
  • 2
    Tai ES, Lau TN, Ho SC, Fok AC, Tan CE. Body fat distribution and cardiovascular risk in normal weight women. Associations with insulin resistance, lipids and plasma leptin. Int J Obes Relat Metab Disord 2000; 24: 751757.
  • 3
    Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. Arch Intern Med 2002; 162: 20742079.
  • 4
    DiPietro L, Katz LD, Nadel ER. Excess abdominal adiposity remains correlated with altered lipid concentrations in healthy older women. Int J Obes Relat Metab Disord 1999; 23: 432436.
  • 5
    Kurth T, Gaziano JM, Berger K et al. Body mass index and the risk of stroke in men. Arch Intern Med 2002; 162: 25572562.
  • 6
    Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 16251638.
  • 7
    Behn A, Ur E. The obesity epidemic and its cardiovascular consequences. Curr Opin Cardiol 2006; 21: 353360.
  • 8
    Damcott CM, Sack P, Shuldiner AR. The genetics of obesity. Endocrinol Metab Clin North Am 2003; 32: 761786.
  • 9
    Loftus TM, Jaworsky DE, Frehywot GL et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 23792381.
  • 10
    Blüher M, Michael MD, Peroni OD et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 3: 2538.
  • 11
    Boizard M, Le Liepvre X, Lemarchand P et al. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem 1998; 273: 2916429171.
  • 12
    Claycombe KJ, Jones BH, Standridge MK et al. Insulin increases fatty acid synthase gene transcription in human adipocytes. Am J Physiol 1998; 274: R1253R1259.
  • 13
    Semenkovich CF. Regulation of fatty acid synthase (FAS). Prog Lipid Res 1997; 36: 4353.
  • 14
    Berndt J, Kovacs P, Ruschke K et al. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 2007; 50: 14721480.
  • 15
    Norman RA, Tataranni PA, Pratley R et al. Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet 1998; 62: 659668.
  • 16
    Kovacs P, Harper I, Hanson RL et al. A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Diabetes 2004; 53: 19151919.
  • 17
    Körner A, Ma L, Franks PW et al. Sex-specific effect of the Val1483Ile polymorphism in the fatty acid synthase gene (FAS) on body mass index and lipid profile in Caucasian children. Int J Obes (Lond) 2007; 31: 353358.
  • 18
    Chirala SS, Jayakumar A, Gu ZW, Wakil SJ. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Proc Natl Acad Sci USA 2001; 98: 31043108.
  • 19
    Bergman RN, Prager R, Volund A, Olefsky JM. Equivalence of the insulin sensitivity index in man derived by the minimal model method and euglycaemic glucose clamp. J Clin Invest 1987; 79: 790800.
  • 20
    Cervero P Botas, Alvarez E Delgado, Fernández G Castaño, De Greñu C Díaz, Santiago J Prieto. Prevalence of diabetes mellitus and glucose intolerance in the population aged 30 to 75 years in Asturias, Spain. Rev Clin Esp 2002; 202: 421429.
  • 21
    Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 (Suppl 1): S5S20.
  • 22
    Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412419.
  • 23
    Bonora E, Targher G, Alberiche M et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 5763.
  • 24
    Shillabeer G, Hornford J, Forden JM et al. Fatty acid synthase and adipsin mRNA levels in obese and lean JCR:LA-cp rats: effect of diet. J Lipid Res 1992; 33: 3139.
  • 25
    Nepokroeff CM, Lakshmanan MR, Porter JW. Fatty acid synthase from rat liver. Methods Enzymol 1975; 35: 3744.
  • 26
    Jayakumar A, Chirala SS, Wakil SJ. Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. Proc Natl Acad Sci USA 1997; 94: 1232612330.
  • 27
    Thupari JN, Landree LE, Ronnett GV, Kuhajda FP. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 2002; 99: 94989502.
  • 28
    Naaz A, Holsberger DR, Iwamoto GA et al. Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. FASEB J 2004; 18: 19251927.
  • 29
    Viglietto G, Motti ML, Fusco A. Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization. Cell Cycle 2002; 1: 394400.