The first two authors contributed equally to this work.
Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse
Article first published online: 6 SEP 2012
2010 North American Association for the Study of Obesity (NAASO)
Volume 18, Issue 9, pages 1861–1863, September 2010
How to Cite
Contreras-Alcantara, S., Baba, K. and Tosini, G. (2010), Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse. Obesity, 18: 1861–1863. doi: 10.1038/oby.2010.24
- Issue published online: 6 SEP 2012
- Article first published online: 6 SEP 2012
- Received 20 October 2009; accepted 23 January 2010
The incidence of obesity, insulin resistance, and type 2 diabetes (T2D) is increasing at an alarming rate worldwide. Emerging experimental evidence suggests that the hormone melatonin plays an important role in the regulation of glucose metabolisms. In this study, we report that removal of melatonin receptor type 1 (MT1) significantly impairs the ability of mice to metabolize glucose and such inability is probably due to an increased insulin resistance in these mice. Our data suggest that MT1 receptors are implicated in the pathogenesis of T2D and open the door for a detailed exploration on the mechanisms by which MT1 receptors signaling may affect glucose metabolism.