Relations of Circulating Resistin and Adiponectin and Cardiac Structure and Function: The Framingham Offspring Study

Authors

  • David D. McManus,

    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
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  • Asya Lyass,

    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    2. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
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  • Erik Ingelsson,

    1. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
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  • Joseph M. Massaro,

    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    2. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
    3. Department of Mathematics, Boston University School of Public Health, Boston, Massachusetts, USA
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  • James B. Meigs,

    1. Department of Medicine and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
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  • Jayashri Aragam,

    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    2. Veterans Administration Hospital, West Roxbury, Massachusetts, USA
    3. Harvard Medical School, Boston, Massachusetts, USA
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  • Emelia J. Benjamin,

    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    2. Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, Massachusetts, USA
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  • Ramachandran S. Vasan

    Corresponding author
    1. National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA
    2. Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, Massachusetts, USA
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(vasan@bu.edu)

Abstract

Obesity is associated with pathological cardiac remodeling and risk of heart failure (HF). Adipocytokines (ADKs) may mediate the increased risk of cardiovascular disease associated with excess adiposity. Yet data relating ADKs to cardiac remodeling phenotypes are sparse. We related two circulating ADKs, resistin and adiponectin, to three important echocardiographic markers of cardiac remodeling, left ventricular mass (LVM), left atrial diameter (LAD), and LV fractional shortening (LVFS) in 2,615 participants (mean age 61 years, 55% women) in the Framingham Offspring Study. Adiponectin concentrations were inversely related to LVM in multivariable linear regression models adjusting for key clinical correlates including BMI (regression coefficient per s.d.-increment in ln-adiponectin = −3.37, P = 0.02; P for trend across quartiles = 0.02). Adiponectin was not associated with LAD or LVFS (P > 0.56). Resistin concentrations were inversely related to LVFS (regression coefficient per s.d.-increment in ln-resistin = −0.01, P = 0.03; P for trend across quartiles = 0.04). Resistin was not associated with LVM or LAD (P > 0.05). In our moderate-sized, community-based sample, higher circulating concentrations of adiponectin and resistin were associated with lower LVM and lower LVFS, respectively. In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk.

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