Weight Loss Is Associated With Increased Serum 25-Hydroxyvitamin D in Overweight or Obese Women

Authors

  • Cheryl L. Rock,

    Corresponding author
    1. Department of Family and Preventive Medicine, and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA
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  • Jennifer A. Emond,

    1. Department of Family and Preventive Medicine, and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA
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  • Shirley W. Flatt,

    1. Department of Family and Preventive Medicine, and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA
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  • Dennis D. Heath,

    1. Department of Family and Preventive Medicine, and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA
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  • Njeri Karanja,

    1. Kaiser Permanente Center for Health Research, Portland, Oregon, USA
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  • Bilge Pakiz,

    1. Department of Family and Preventive Medicine, and Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA
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  • Nancy E. Sherwood,

    1. HealthPartners Research Foundation, and Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
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  • Cynthia A. Thomson

    1. Department of Nutritional Sciences and the Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA
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(clrock@ucsd.edu)

Abstract

Low circulating concentrations of vitamin D metabolites have been associated with increased risk for several diseases and clinical conditions. Large observational studies and surveys have shown that obesity is independently associated with lower serum 25-hydroxyvitamin D (25(OH)D) concentration. Few studies have examined the effect of weight loss on serum 25(OH)D concentration. The purpose of this study was to prospectively examine the effect of weight loss on serum 25(OH)D concentration. Data were collected from 383 overweight or obese women who participated in a 2-year clinical trial of a weight-loss program, in which 51% (N = 195) lost at least 5% of baseline weight by 24 months, 18% (N = 67) lost 5–10%, and 33% (N = 128) lost >10%. Women who did not lose weight at 24 months had an increase in serum 25(OH)D of 1.9 (9.7) ng/ml (mean (SD)); 25(OH)D increased by 2.7 (9.1) ng/ml for those who lost 5–10% of baseline weight; and 25(OH)D increased by 5.0 (9.2) ng/ml for those who lost >10% of baseline weight (P = 0.014). At baseline, 51% (N = 197) of participants met or exceeded the recommended serum concentration of 20 ng/ml. By study end, 64% (N = 230) of overweight or obese women met this goal, as well as 83% (N = 20) of those whose weight loss achieved a normal BMI. These findings suggest that weight loss, presumably associated with a reduction in body fat, is associated with increased serum 25(OH)D concentration in overweight or obese women.

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