• Abila, B., Richens, A. & Davies, J.A. (1993). Anticonvulsant effects of extracts of the West African black pepper, Piper guineense. J. Ethnopharmacol., 39, 113117.
  • Aram, J.A., Martin, D., Tomczyk, M., Millar, J., Pohler, G. & Lodge, D. (1989). Neocortical epileptogenesis in vitro: studies with NMDA, PCP, sigma and dextromethorphan receptor ligands. J. Pharmacol. Exp. Ther., 248, 320328.
  • Dickie, B.G.M., Annels, S.J. & Davies, J.A. (1994). Effects of cyclooxygenase inhibition upon glutamate release from rat cerebellum. NeuroReport, 5, 393396.
  • Dickie, B.G.M. & Davies, J.A. (1992). Calcium blocking agents and potassium-stimulated release of glutamate from cerebellar slices. Eur. J. Pharmacol., 229, 9799.
  • Dimpfel, W., Chatterjee, S.S., Noldner, M. & Ticku, M.K. (1995). Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system. Epilepsia, 36, 983989.
  • Horne, A.L., Harrison, N.L., Turner, J.P. & Simmonds, M.A. (1986). Spontaneous paroxysmal activity induced by zero magnesium and bicuculline: suppression by NMDA antagonists and GABA mimetics. Eur. J. Pharmacol., 122, 231238.
  • Hu, R.Q. & Davies, J.A. (1995). The effect of the desglycinyl metabolite of remacemide on cortical wedges prepared from DBA/2 mice. Eur. J. Pharmacol., 287, 251256.
  • Huntley, G.W., Vickers, J.C. & Morrison, J.H. (1994). Cellular and synaptic localization of NMDA and non-NMDA receptor subunits in neocortex: organizational features related to cortical circuitry, function and disease. Trends Neurosci., 17, 536543.
  • Jobe, P., Mishra, P., Luig, N. & Dailey, W. (1991). Sope and contribution of genetic models to an understanding of epilepsy. Neurobiology, 6, 183220.
  • Kaptenovic, I.M., Yonekawa, W. & Kupferberg, H.J. (1995). The effects of anticonvulsant compounds on 4-aminopyridine-induced de novo synthesis of neurotransmitter amino acids in rat hippocampus in vitro. Epilepsy Res., 20, 113120.
  • Kohr, G. & Heinemann, U. (1990a). Effects of tetronic acid derivatives AO-33 (losigamone) and AO-78 on epileptiform activity in rat hippocampal slices. Epilepsy Res., 7, 4955.
  • Kohr, G. & Heinemann, U. (1990b). Anticonvulsant properties of tetronic acid derivatives on picrotoxin-induced epileptiform activity in rat hippocampal slices. Neurosci. Lett., 112, 4347.
  • Leach, M.J., Marden, C.M. & Miller, A.A. (1986). Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia, 27, 490497.
  • Leschinger, A., Stabel, J., Igelmund, P. & Heineman, U. (1993). Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration. Exp. Brain Res., 96, 230240.
  • Levi, G., Gallo, V. & Raiteri, M. (1980). A re-evaluation of veratridine as a tool for studying the depolarisation-induced release of neurotransmitter from nerve-endings. Neurochem. Res., 5, 281295.
  • Meldrum, B.S. (1992). Excitatory amino acids in epilepsy and potential novel therapies. Epilepsy Res., 12, 189196.
  • Minchin, M.C.W. (1980). Veratrum alkaloids as transmitter-releasing agents. J. Neurosci. Meth., 2, 111112.
  • Montague, P.R., Gancayco, C.D., Winn, M.J., Marchase, R.B. & Friedlander, M.J. (1994). Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science, 263, 973977.
  • Palmer, A.J., Zeman, S. & Lodge, D. (1992). Methohexitone antagonises kainate and epileptiform activity in rat neocortical slices. Eur. J. Pharmacol., 221, 205209.
  • Rowley, H.L., Ellis, Y. & Davies, J.A. (1993). Age-related effects of NMDA-stimulated concomitant release of nitric oxide and glutamate in cortical slices prepared from DBA/2 mice. Brain Res., 613, 4953.
  • Schmitz, D., Glovelli, T. & Heinemann, U. (1995). Effect of losigamone on synaptic potentials and spike frequency habituation in rat entorhinal cortex and hippocampal CA1 neurones. Neurosci. Lett., 200, 141143.
  • Srinivasan, J., Richens, A. & Davies, J.A. (1995). The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex. Br. J. Pharmacol., 116, 30873092.
  • Stein, U. (1995). Losigamone. In Antiepileptic Drugs, ed. Levy, R., Mattson, R. & Meldrum, B. pp. 10251034. New York: Raven Press.
  • Yonekawa, W.D., Kapetanovic, I.M. & Kupferberg, H.J. (1995). The activity in rat hippocampus in vitro. Epilepsy Res., 20, 137150.