• CASTRO, S.W., BUELL, G., FENIUK, W. & HUMPHREY, P.P.A. (1996). Differences in the operational characteristics of the human recombinant somatostatin receptor types, sst1 and sst2, in mouse fibroblast (Ltk-) cells. Br. J. Pharmacol., 117, 639646.
  • CHESSELL, I.P., BLACK, M.D., FENIUK, W. & HUMPHREY, P.P.A. (1996). Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones. Br. J. Pharmacol, 117, 16731678.
  • CHIU, T.H., YEH, M.H. & CHEN, M.E. (1994). Actions of a long-acting somatostatin analog Sms201–995 (Sandostatin) on rat locus coeruleus neurones. Life Sci., 54, 13131320.
  • CHIENG, B., CONNOR, M. & CHRISTIE, M.I. (1996). The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)], produces a non- opioid receptor mediated increase in K+ conductance of rat locus coeruleus neurones. Mol. Pharmacol, 50, 650655.
  • CONNOR, M., CHIENG, B. & CHRISTIE, M.I. (1996a). Cortistatin and Ctop activate somatostatin receptors in rat locus coeruleus neurones in vitro. Proc. Aust. Soc. Clin. Exp. Pharmacol ToxicoL, 3, P19.
  • CONNOR, M., VAUGHAN, C.W., CHIENG, B. & CHRISTIE, M.I. (1996b). Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro. Br. J. Pharmacol, 119, 16141618.
  • CONNOR, M., YEO, A. & HENDERSON, G. (1997). Neuropeptide Y Y2 and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in Sh-SY5Y human neuroblastoma cells. Br. J. Pharmacol, 120, 455463.
  • DE LECEA, L., CRIADO, I.R., PROSPERO-GARCIA, O., GAUTVIK, K.M., SCHWEITZER, P., DANIELSON, P.E., DUNLOP, C.L.M., SIGGINS, G.R., HENRIKSEN, S.I. & SUTCLIFFE, I.G. (1996). A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature, 381, 242245.
  • FENIUK, W., DIMECH, J. & HUMPREHY, P.P.A. (1993). Characterization of somatostatin receptors in guinea-pig isolated ilem, vas deferens and right atrium. Br. J. Pharmacol., 110, 11561164.
  • FIORILLO, CD. & WILLIAMS, J.T. (1996). Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleus. J. Neurosci., 16, 14791485.
  • FUKUSUMI, S., KITADA, C, TAKEKAWA, S., KIZAWA, H., SAKAMOTO, J., MIYAMOTO, M., HINUMA, S., KITANO, K. & FUJINO, M. (1997). Identification of and characterization of a novel human cortistatin-like peptide. Biochem. Biophys. Res. Commun., 232, 157163.
  • HARRIS, G.C. & WILLIAMS, J.T. (1991). Transient homologous μ-opioid receptor desensitization in rat locus coeruleus neurones. J. Neurosci., 11, 25742581.
  • INOUE, M., NAKAJIMA, S. & NAKAJIMA, Y. (1988). Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin-sensitive mechanism. J. Physiol., 407, 177198.
  • MAURER, R., GAEHWILER, B.H., BUESCHER, H.H., HILL, R.R. & ROEMER, D. (1982). Opiate antagonistic properties of an octapeptide somatostatin analogue. Proc. Natl. Acad. Sci. U.S.A., 79, 48154817.
  • MIHARA, S., NORTH, R.A. & SUPRENANT, A. (1987). Somatostatin increases an inwardly rectifying potassium conductance in guinea-pig submucous plexus neurones. J. Physiol., 390, 335355.
  • OSBORNE, P.B., VAUGHAN, C.W., WILSON, H.I. & CHRISTIE, M.J. (1996). Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro. J. Physiol., 490, 383389.
  • PELTON, J.T., KAZMIERSKI, W., GULYA, K., YAMAMURA, H.I. & HRUBY, V.J. (1986). Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J. Med. Chem., 29, 23702375.
  • TERENIUS, L. (1976). Somatostatin and Acth are peptides with partial antagonist-like selectivity for opiate receptors. Eur. J. Pharmacol., 38, 211213.
  • TRAVAGLI, R.A., DUNWIDDIE, T.V. & WILLIAMS, J.T. (1995). Opioid inhibition in locus coeruleus. J. Neurophysiol., 74, 519528.
  • VEBER, D.F., HOLLY, F.W., NUTT, R.F., BERGSTRAND, S.J., BRADY, S.F., HIRSHMANN, R., GLITZER, M.S. & SAPERSTEIN, R. (1979). Highly active cyclic and bicyclic somatostatin analogues of reduced ring size. Nature, 280, 512514.