• BOUABOULA, M., PERRACHON, S., MILLIGAN, L., CANAT, X., RINALDI-CARMONA, M., PORTIER, M., BARTH, F., CALANDRA, B., PECCEU, F., LUPKER, J., MAFFRAND, J.-P., LE FUR, G. & CASSELLAS, P. (1997). A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J. Biol. Chem., 272, 2233022339.
  • BREIVOGEL, C.S., SIM, L.J. & CHILDERS, S.R. (1997). Regional differences in cannabinoid receptor G-protein coupling in rat brain. J. Pharmacol. Exp. Ther., 282, 16321642.
  • CHENG, Y.-C. & PRUSOFF, W.H. (1973). Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction. Biochem. Pharmacol., 22, 30993108.
  • COLQUHOUN, D. (1971). Lectures on Biostatistics. Oxford University Press., Oxford.
  • COMPTON, D.R., RICE, K.C., DE COSTA, B.R., RAZDAN, R.K., MELVIN, L.S., JOHNSON, M.R. & MARTIN, B.R. (1993). Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. J. Pharmacol. Exp. Ther., 265, 218226.
  • FELDER, C.C., JOYCE, K.E., BRILEY, E.M., MANSOURI, J., MACKIE, K., BLOND, O., LAI, Y., MA, A.L. & MITCHELL, R.L. (1995). Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol. Pharmacol., 48, 443450.
  • GAREAU, Y., DUFRESNE, C., GALLANT, M., ROCHETTE, C., SAWYER, N., SLIPETZ, D.M., TREMBLAY, N., WEECH, P.K., METTERS, K.M. & LABELLE, M. (1996). Structure activity relationships of tetrahydrocannabinol analogues on human cannabinoid receptors. Bioorg. Med. Chem. Letts., 6, 189194.
  • GLASS, M. & FELDER, C.C. (1997). Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J. Neuroscience, 17, 53275333.
  • GREEN, A., O'SHAUGHNESSY, C., DISNEY, G., WHITTINGTON, A., REES, S., LEE, M. & MARSHALL, F. (1998). Reporter assays for human cannabinoid CB1 and CB2 receptors for the identification of novel agonists. Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, 102.
  • GRIFFIN, G., FERNANDO, S.R., ROSS, R.A., MCKAY, N.G., ASHFORD, M.L.J., SHIRE, D., HUFFMAN, J.W., YU, S., LAINTON, J.A.H. & PERTWEE, R.G. (1997). Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. Eur. J. Pharmacol., 339, 5361.
  • HOSOHATA, K., QUOCK, R.M., HOSOHATA, Y., BURKEY, T.H., MAKRIYANNIS, A., CONSROE, P., ROESKE, W.R. & YAMAMURA, H.I. (1997a). AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci., 61, PL115118.
  • HOSOHATA, Y., QUOCK, R.M., HOSOHATA, K., MAKRIYANNIS, A., CONSROE, P., ROESKE, W.R. & YAMAMURA, H.I. (1997b). AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain. Eur. J. Pharmacol., 321, R1R3.
  • KENAKIN, T. (1995). Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity. Trends Pharmacol. Sci., 16, 188192.
  • LANDSMAN, R.S., MAKRIYANNIS, A., DENG, H., CONSROE, P., ROESKE, W.R. & YAMAMURA, H.I. (1998). AM630 is an inverse agonist at the human cannabinoid CB1 receptor. Life Sci., 62, PL109PL113.
  • MACLENNAN, S.J., REYNEN, P.H., KWAN, J. & BONHAUS, D.W. (1998). Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. Br. J. Pharmacol., 124, 619622.
  • MUNRO, S., THOMAS, K.L. & ABU-SHAAR, M. (1993). Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 6165.
  • PERTWEE, R.G. (1997). Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther., 74, 129180.
  • PERTWEE, R.G. (1998). Cannabinoid receptors and their ligands in brain and other tissues. In Marihuana and Medicine. ed. Nahas, G.G., Sutin, K.M. & Agurell, S., Totowa: Humana Press (in press).
  • PERTWEE, R.G., FERNANDO, S.R., NASH, J.E. & COUTTS, A.A. (1996). Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine. Br. J. Pharmacol., 118, 21992205.
  • PERTWEE, R., GRIFFIN, G., FERNANDO, S., LI, X., HILL, A. & MAKRIYANNIS, A. (1995). AM630, a competitive cannabinoid receptor antagonist. Life Sci., 56, 19491955.
  • RINALDI-CARMONA, M., BARTH, F., MILLAN, J., DEROCQ, J.-M., CASSELLAS, P., CONGY, C., OUSTRIC, D., SARRAN, M., BOUABOULA, M., CALANDRA, B., PORTIER, M., SHIRE, D., BRELIERE, J.-C. & LE FUR, G. (1998). SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J. Pharmacol. Exp. Ther., 284, 644650.
  • SHOWALTER, V.M., COMPTON, D.R., MARTIN, B.R. & ABOOD, M.E. (1996). Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J. Pharmacol. Exp. Ther., 278, 989999.