Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats
Article first published online: 29 JAN 2009
1999 British Pharmacological Society
British Journal of Pharmacology
Volume 128, Issue 2, pages 419–427, September 1999
How to Cite
Yamada, K., Tanaka, T., Zou, L.-B., Senzaki, K., Yano, K., Osada, T., Ana, O., Ren, X., Kameyama, T. and Nabeshima, T. (1999), Long-term deprivation of oestrogens by ovariectomy potentiates β-amyloid-induced working memory deficits in rats. British Journal of Pharmacology, 128: 419–427. doi: 10.1038/sj.bjp.0702811
- Issue published online: 29 JAN 2009
- Article first published online: 29 JAN 2009
- (Received March 15, 1999, Revised May 12, 1999, Accepted June 30, 1999)
- Alzheimer's disease;
- amyloid β-peptide;
- spatial memory
In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused by a continuous intracerebroventricular (i.c.v.) infusion of amyloid β-peptide (Aβ), the major constituent of senile plaques in AD.
Neither long-term (3 months) nor short-term (1 month), deprivation of oestrogens by ovariectomy caused a significant impairment in spatial learning and memory in a water maze and spontaneous alternation behaviour in a Y-maze.
A continuous i.c.v. infusion of Aβ-(1-42) caused spatial learning and memory deficits in both ovariectomized and sham-operated rats.
The Aβ-induced working memory deficits were significantly potentiated in ovariectomized rats compared with sham-operated rats when mnemonic ability was examined 3 months after ovariectomy.
These results suggest that long-term deprivation of oestrogens induced by ovariectomy increases susceptibility to memory deficits produced by Aβ-(1-42) in rats.
British Journal of Pharmacology (1999) 128, 419–427; doi:10.1038/sj.bjp.0702811