Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety
Article first published online: 29 JAN 2009
2000 Nature Publishing Group
British Journal of Pharmacology
Volume 130, Issue 4, pages 739–746, June 2000
How to Cite
Podhorna, J. and Brown, R. E. (2000), Flibanserin has anxiolytic effects without locomotor side effects in the infant rat ultrasonic vocalization model of anxiety. British Journal of Pharmacology, 130: 739–746. doi: 10.1038/sj.bjp.0703364
- Issue published online: 29 JAN 2009
- Article first published online: 29 JAN 2009
- (Received November 25, 1999, Revised March 6, 2000, Accepted March 15, 2000)
- ultrasonic vocalization;
- negative geotaxis;
- rat pups
This study compared the effects of flibanserin, a novel 5-HT1A agonist/5-HT2A antagonist; diazepam, a traditional anxiolytic; and imipramine, a traditional antidepressant, on separation-induced ultrasonic vocalizations (USVs), locomotor behaviour, negative geotaxis and body temperature of 7–8-day-old rat pups.
Flibanserin (5, 10, 25 and 50 mg kg−1 s.c.) reduced USVs but had no effects on locomotor behaviour or negative geotaxis. Lower doses of flibanserin (0.5, 1, 2 and 4 mg kg−1 s.c.) had no effect on any behaviour. Diazepam (0.25, 0.5, 1 and 2 mg kg−1 s.c.) not only reduced the USVs but also increased rolling and increased the latency of the negative geotaxic response. Imipramine (10, 15, 20 and 30 mg kg−1 s.c.) reduced USVs, increased total locomotor activity and rolling but had no effect on negative geotaxis. None of the drugs altered body temperature.
Our data showed that flibanserin is as effective in reducing the USVs as diazepam and imipramine but has a lower incidence of motor side effects. This suggests that flibanserin might be effective for the treatment of mood disturbances such as anxiety.
British Journal of Pharmacology (2000) 130, 739–746; doi:10.1038/sj.bjp.0703364