• AMEMIYA, N., HATTA, S., TAKEMURA, H. & OHSHIKA, H. (1996). Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips. Eur. J. Pharmacol., 318, 403409.
  • ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 4854.
  • AZPIROZ, F. & MALAGELADA, J.R. (1987). Importance of vagal input in maintaining gastric tone in the dog. J. Physiol., 384, 511524.
  • BERMUDEZ, J., DUNBAR, A., SANGER, G.J. & TURNER, D.H. (1990). Stimulation of canine gastric motility by BRL 24924, a new gastric prokinetic agent. J. Gastrointest. Motility, 2, 281286.
  • BINGHAM, S., KING, B.F., RUSHANT, B., SMITH, M.I., GASTER, L. & SANGER, G.J. (1995). Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. J. Pharm. Pharmacol., 47, 219222.
  • BLACK, J.W., LEFF, P. & SHANKLEY, N.P. (1985). Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay. Br. J. Pharmacol., 86, 581587.
  • BRIEJER, M.R., AKKERMANS, L.M.A. & SCHUURKES, J.A.J. (1995). Gastrointestinal prokinetic benzamides: the pharmacology underlying stimulation of motility. Pharmacol. Rev., 47, 631651.
  • BRIEJER, M.R., GHOOS, E., EELEN, J. & SCHUURKES, J.A.J. (1998a). Serotonin 5-HT4 receptors mediate the R093877-induced changes in contractile patterns in the canine colon. Gastroenterology, 112, A705.
  • BRIEJER, M.R., MEULEMANS, A.L., WELLENS, A. & SCHUURKES, J.A.J. (1998b). R093877 dose-dependently accelerates delayed gastric emptying in conscious dogs. Gastroenterology, 112, A705.
  • BRIEJER, M.R., VAN DAELE, P., BOSMANS, J.-P., GHOOS, E., EELEN, J. & SCHUURKES, J.A.J. (1998c). Dose-dependent effects after oral and intravenous administration of R093877 on colonic motility in conscious dogs. Gastroenterology, 112, A705.
  • BUCHHEIT, K.H. & BUHL, T. (1994). Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro. Eur. J. Pharmacol., 262, 9197.
  • DE RIDDER, W.J. & SCHUURKES, J.A.J. (1993). Cisapride and 5-hydroxytryptamine enhance motility in the canine antrum via separate pathways, not involving 5-hydroxytryptamine1,2,3,4 receptors. J. Pharmacol. Exp. Ther., 264, 7988.
  • GALE, J.D., GREEN, A., DARTON, J., SARGENT, R.S., CLAYTON, N.M. & BUNCE, K.T. (1994c). GR125487: A 5-HT4 receptor antagonist with a long duration of action in vivo. Br. J. Pharmacol., 113, (Suppl.): 119P.
  • GALE, J.D., GROSSMAN, C., DARTON, J., BUNCE, K.T., WHITEHEAD, J.W.F., KNIGHT, J., PARKHOUSE, T.J., OXFORD, A.W. & HUMPHREY, P.P.A. (1994a). GR125487: A selective and high affinity 5-HT4 receptor antagonist. Br. J. Pharmacol., 113, Suppl.): 120P.
  • GALE, J.D., GROSSMAN, C.J., WHITEHEAD, J.W., OXFORD, A.W., BUNCE, K.T. & HUMPHREY, P.P. (1994b). GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. Br. J. Pharmacol., 111, 332338.
  • GULLIKSON, G.W., VIRINA, M.A., LOEFFLER, R.F., YANG, D.C., GOLDSTIN, B., WANG, S.X., MOUMMI, C., FLYNN, D.L. & ZABROWSKI, D.L. (1993). SC-49518 enhances gastric emptying of solid and liquid meals and stimulates gastrointestinal motility in dogs by a 5-hydroxytryptamine4 receptor mechanism. J. Pharmacol. Exp. Ther., 264, 240248.
  • HEGDE, S.S. & EGLEN, R.M. (1996). Peripheral 5-HT4 receptors. FASEB, 10, 13981407.
  • JOHNSON, A.G. (1989). The effects of cisapride on antroduodenal co-ordination and gastric emptying. Scand. J. Gastroent. Supp., 165, 3643.
  • LUX, G., KATSCHINSKI, M., LUDWIG, S., LEDERER, P., ELLERMAN, A & DOMSCHKE, W. (1994). The effect of cisapride and metoclopramide on human digestive and interdigestive antroduodenal motility. Scand. J. Gastroent., 29, 11051110.
  • MATSUYAMA, S., SAKIYAMA, H., NEI, K. & TANAKA, C. (1996). Identification of putative 5-hydroxytryptamine(4) (5-HT4) receptors in guinea pig stomach: The effect of TKS159, a novel agonist, on gastric motility and acetylcholine release. J. Pharmacol. Exp. Ther., 276, 989995.
  • MEULEMANS, A.L. & SCHUURKES, J.A. (1992). Is the action of cisapride on the guinea-pig ileum mediated via 5-HT4 receptors Eur. J. Pharmacol., 212, 5159.
  • PRINS, N.H., SHANKLEY, N.P., WELSH, N.J., BRIEJER, M.R., LEFEBVRE, R.A., AKKERMANS, L.M.A. & SCHUURKES, J.A.J. (2000). An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestinal circular muscle. Br. J. Pharmacol., 129, 16011608.
  • PRINS, N.H., VAN HASELEN, J.F.W.R., LEFEBVRE, R.A., BRIEJER, M.R., AKKERMANS, L.M.A. & SCHUURKES, J.A.J. (1999). Pharmacological characterization of 5-HT4 receptor mediating relaxation of canine isolated rectum circular smooth muscle. Br. J. Pharmacol., 127, 14311437.
  • SAKURAI-YAMASHITA, Y., TAKADA, K., TAKEMURA, K., YAMASHITA, K., ENJOJI, A., KANEMATSU, T. & TANIYAMA, K. (1999). Ability of mosapride to bind to 5-HT4 receptors in the human stomach. Jap. J. Pharmacol., 79, 493496.
  • SCHUURKES, J.A., VAN NUETEN, J.M., VAN DAELE, P.G., REYNTJENS, A.J. & JANSSEN, P.A. (1985). Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J. Pharmacol. Exp. Ther., 234, 775783.
  • SCHUURKES, J.A.J., MEULEMANS, A.L., OBERTOP, H. & AKKERMANS, L.M.A. (1991). 5-HT4 receptors on the human stomach. J. Gastrointest. Mot., 3, 199.
  • TAKADA, K., SAKURAI-YAMASHITA, Y., YAMASHITA, K., KAIBARA, M., HAMADA, Y., NAKANE, Y., HIOKI, K. & TANIYAMA, K. (1999). Regional difference in correlation of 5-HT4 receptor distribution with cholinergic transmission in the guinea pig stomach. Eur. J. Pharmacol., 374, 489494.