• EGUCHI, N., MINAMI, T., SHIRAFUJI, N., KANAOKA, Y., TANAKA, T., NAGATA, A., YOSHIDA, N., URADE, Y., ITO, S. & HAYAISHI, O. (1999). Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc. Natl. Acad. Sci. U.S.A., 96, 726730.
  • HUNSKAAR, S. & HOLE, K. (1987). The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain, 30, 103114.
  • HYLDEN, J.L.K. & WILCOX, G.L. (1980). Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol., 67, 313316.
  • KUMAZAWA, T., MIZUMURA, K., KODA, H. & FUKUSAKO, H. (1996). EP receptor subtypes implicated in the PGE2-induced sensitization of polymodal receptors in response to bradykinin and heat. J. Neurophysiol., 75, 23612368.
  • MALMBERG, A.B., RAFFERTY, M.F. & YAKSH, T.L. (1994). Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci. Lett., 173, 193196.
  • MALMBERG, A.B. & YAKSH, T.L. (1992a). Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science, 257, 12761279.
  • MALMBERG, A.B. & YAKSH, T.L. (1992b). Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther., 263, 136146.
  • MALMBERG, A.B. & YAKSH, T.L. (1995). Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanaesthetized rats. J. Neurosci., 15, 27682776.
  • MINAMI, T., NISHIHARA, I., ITO, S., SAKAMOTO, K., HYODO, M. & HAYAISHI, O. (1995a). Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F in conscious mice. Pain, 61, 285290.
  • MINAMI, T., NISHIHARA, I., SAKAMOTO, K., ITO, S., HYODO, M. & HAYAISHI, O. (1995b). Blockade by ONO-NT-012, a unique prostanoid analogue, of prostaglandin E2-induced allodynia in conscious mice. Br. J. Pharmacol., 115, 7376.
  • MINAMI, T., NISHIHARA, I., UDA, R., ITO, S., HYODO, M. & HAYAISHI, O. (1994a). Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice. Br. J. Pharmacol., 112, 735740.
  • MINAMI, T., NISHIHARA, I., UDA, R., ITO, S., HYODO, M. & HAYAISHI, O. (1994b). Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F injected into conscious mice. Pain, 57, 225231.
  • MINAMI, T., OKUDA-ASHITAKA, E., HORI, Y., SAKUMA, S., SUGIMOTO, T., SAKIMURA, K., MISHINA, M. & ITO, S. (1999). Involvement of primary afferent C-fibres in touch-evoked pain (allodynia) induced by prostaglandin E2. Eur. J. Neurosci., 11, 18491856.
  • MINAMI, T., UDA, R., HORIGUCHI, S., ITO, S., HYODO, M. & HAYAISHI, O. (1994c). Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. Pain, 57, 217223.
  • MURATA, T., USHIKUBI, F., MATSUOKA, T., HIRATA, M., YAMASAKI, A., SUGIMOTO, Y., ICHIKAWA, A., AZE, Y., TANAKA, T., YOSHIDA, N., UENO, A., OH-ISHI, S. & NARUMIYA, S. (1997). Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature, 388, 678680.
  • NAKANO, H., MINAMI, T., ABE, K., ARAI, T., TOKUMURA, M., IBII, N., OKUDA-ASHITAKA, E., MORI, H. & ITO, S. (2000). Effect of intrathecal nocistatin on the formalin-induced pain in mice versus that of nociceptin/orphanin FQ. J. Pharmacol. Exp. Ther., 292, 331336.
  • NARUMIYA, S., SUGIMOTO, Y. & USHIKUBI, F. (1999). Prostanoid receptors: structures, properties, and functions. Physiol. Rev., 79, 11931226.
  • NISHIHARA, I., MINAMI, T., WATANABE, Y., ITO, S. & HAYAISHI, O. (1995). Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord. Neurosci. Lett., 196, 5760.
  • SAKAI, M., MINAMI, T., HARA, N., NISHIHARA, I., KITADE, H., KAMIYAMA, Y., OKUDA, K., TAKAHASHI, H., MORI, H. & ITO, S. (1998). Stimulation of nitric oxide release from rat spinal cord by prostaglandin E2. Br. J. Pharmacol., 123, 890894.
  • TAIWO, Y.O. & LEVINE, J.D. (1988). Prostaglandins inhibit endogenous pain control mechanism by blocking transmission at spinal noradrenergic synapses. J. Neurosci., 8, 13461349.
  • UDA, R., HORIGUCHI, S., ITO, S., HYODO, M. & HAYAISHI, O. (1990). Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F to conscious mice. Brain Res., 510, 2632.
  • USHIKUBI, F., SEGI, E., SUGIMOTO, Y., MURATA, T., MATSUOKA, T., KOBAYASHI, T., HIZAKI, H., TUBOI, K., KATSUYAMA, M., ICHIKAWA, A., TANAKA, T., YOSHIDA, N. & NARUMIYA, S. (1998). Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature, 395, 281284.
  • VANE, J.R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin like drugs. Nature New Biol., 231, 232235.
  • YAKSH, T.L., HUA, X.-Y., KALCHEVA, I., NOZAKI-TAGUCHI, N. & MARSALA, M. (1999). The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc. Natl. Acad. Sci. U.S.A., 96, 76807686.
  • ZACHAROWSKI, K., OLBRICH, A., PIPER, J., HAFNER, G., KONDO, K. & THIEMERMANN, C. (1999). Selective activation of the prostanoid EP3 receptor reduces myocardial infarct size in rodents. Arterioscler. Thromb. Vasc. Biol., 19, 21412147.
  • ZIMMERMANN, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109110.