The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats
Article first published online: 29 JAN 2009
2002 British Pharmacological Society
British Journal of Pharmacology
Volume 135, Issue 1, pages 170–180, January 2002
How to Cite
Mechan, A. O., Esteban, B., O'Shea, E., Elliott, J. M., Colado, M. I. and Green, A. R. (2002), The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to rats. British Journal of Pharmacology, 135: 170–180. doi: 10.1038/sj.bjp.0704442
- Issue published online: 29 JAN 2009
- Article first published online: 29 JAN 2009
- (Received May 23, 2001, Revised October 1, 2001, Accepted October 15, 2001)
- 5-HT antagonists;
- dopamine antagonists;
- GBR 12909;
The pharmacology of the acute hyperthermia that follows 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) administration to rats has been investigated.
MDMA (12.5 mg kg−1 i.p.) produced acute hyperthermia (measured rectally). The tail skin temperature did not increase, suggesting that MDMA may impair heat dissipation.
Pretreatment with the 5-HT1/2 antagonist methysergide (10 mg kg−1), the 5-HT2A antagonist MDL 100,907 (0.1 mg kg−1) or the 5-HT2C antagonist SB 242084 (3 mg kg−1) failed to alter the hyperthermia. The 5-HT2 antagonist ritanserin (1 mg kg−1) was without effect, but MDL 11,939 (5 mg kg−1) blocked the hyperthermia, possibly because of activity at non-serotonergic receptors.
The 5-HT uptake inhibitor zimeldine (10 mg kg−1) had no effect on MDMA-induced hyperthermia. The uptake inhibitor fluoxetine (10 mg kg−1) markedly attenuated the MDMA-induced increase in hippocampal extracellular 5-HT, also without altering hyperthermia.
The dopamine D2 antagonist remoxipride (10 mg kg−1) did not alter MDMA-induced hyperthermia, but the D1 antagonist SCH 23390 (0.3 – 2.0 mg kg−1) dose-dependently antagonized it.
The dopamine uptake inhibitor GBR 12909 (10 mg kg−1) did not alter the hyperthermic response and microdialysis demonstrated that it did not inhibit MDMA-induced striatal dopamine release.
These results demonstrate that in vivo MDMA-induced 5-HT release is inhibited by 5-HT uptake inhibitors, but MDMA-induced dopamine release may not be altered by a dopamine uptake inhibitor.
It is suggested that MDMA-induced hyperthermia results not from MDMA-induced 5-HT release, but rather from the increased release of dopamine that acts at D1 receptors. This has implications for the clinical treatment of MDMA-induced hyperthermia.
British Journal of Pharmacology (2002) 135, 170–180; doi:10.1038/sj.bjp.0704442